TY - JOUR
T1 - Skin nociceptive block with pramoxine delivery by subcutaneous injection in rats
AU - Chou, An Kuo
AU - Chiu, Chong Chi
AU - Chen, Yu Wen
AU - Wang, Jhi Joung
AU - Hung, Ching Hsia
N1 - Funding Information:
The financial support was provided by the China Medical University, Taiwan ( CMU106-S-18 ).
PY - 2018/12
Y1 - 2018/12
N2 - Background: Pramoxine has been shown to produce spinal anesthesia, while cutaneous analgesia (peripheral) of pramoxine is not established. The experimental goal was to examine cutaneous antinociception produced by a local anesthetic (LA) pramoxine and compare this result with that of another well-known LA lidocaine. Methods: Cutaneous antinociception was evaluated by blockade of pinprick- induced cutaneous trunci muscle reflex (CTMR) on the skin of rat's back. After the dose–related curves were constructed, the quality and duration of drug's (lidocaine and pramoxine) cutaneous antinociception were compared. Results: We showed that pramoxine, as well as lidocaine produced skin antinociception in a dose–related fashion. The relative potency (ED50 [50% effective dose] basis) was lidocaine (5.44 [4.67–6.35] μmol) greater than pramoxine (42.1 [38.8–45.7] μmol) (p < 0.01). On the basis of equianalgesic doses (ED75, ED50, and ED25), pramoxine caused equivalent duration of cutaneous antinociception to lidocaine. Conclusions: These preclinical data indicated that pramoxine elicits skin antinociception dose-relatedly. Pramoxine exhibits a potency less than that of lidocaine while they have a comparable duration of skin antinociceptive action.
AB - Background: Pramoxine has been shown to produce spinal anesthesia, while cutaneous analgesia (peripheral) of pramoxine is not established. The experimental goal was to examine cutaneous antinociception produced by a local anesthetic (LA) pramoxine and compare this result with that of another well-known LA lidocaine. Methods: Cutaneous antinociception was evaluated by blockade of pinprick- induced cutaneous trunci muscle reflex (CTMR) on the skin of rat's back. After the dose–related curves were constructed, the quality and duration of drug's (lidocaine and pramoxine) cutaneous antinociception were compared. Results: We showed that pramoxine, as well as lidocaine produced skin antinociception in a dose–related fashion. The relative potency (ED50 [50% effective dose] basis) was lidocaine (5.44 [4.67–6.35] μmol) greater than pramoxine (42.1 [38.8–45.7] μmol) (p < 0.01). On the basis of equianalgesic doses (ED75, ED50, and ED25), pramoxine caused equivalent duration of cutaneous antinociception to lidocaine. Conclusions: These preclinical data indicated that pramoxine elicits skin antinociception dose-relatedly. Pramoxine exhibits a potency less than that of lidocaine while they have a comparable duration of skin antinociceptive action.
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U2 - 10.1016/j.pharep.2018.09.001
DO - 10.1016/j.pharep.2018.09.001
M3 - Article
C2 - 30326418
AN - SCOPUS:85054764482
VL - 70
SP - 1180
EP - 1184
JO - Polish Journal of Pharmacology and Pharmacy
JF - Polish Journal of Pharmacology and Pharmacy
SN - 1734-1140
IS - 6
ER -