TY - JOUR
T1 - Slow evolutionary rate of GB virus C/hepatitis G virus
AU - Suzuki, Yoshiyuki
AU - Katayama, Kazuhiko
AU - Fukushi, Shuetsu
AU - Kageyama, Tsutomu
AU - Oya, Akira
AU - Okamura, Hirofumi
AU - Tanaka, Yasuhito
AU - Mizokami, Masashi
AU - Gojobori, Takashi
PY - 1999
Y1 - 1999
N2 - With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.
AB - With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.
UR - http://www.scopus.com/inward/record.url?scp=0033041307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033041307&partnerID=8YFLogxK
U2 - 10.1007/PL00006482
DO - 10.1007/PL00006482
M3 - Article
C2 - 10079276
AN - SCOPUS:0033041307
SN - 0022-2844
VL - 48
SP - 383
EP - 389
JO - Journal of Molecular Evolution
JF - Journal of Molecular Evolution
IS - 4
ER -
