@article{40f25128470944f5a4d509ba7dbe5493,
title = "Social cognitive deficit is associated with visuomotor coordination impairment and dopamine transporter availability in euthymic bipolar disorder",
abstract = "Background: Extensive evidence has suggested functional connections between co-occurring visuomotor and social cognitive deficits in neuropsychiatric disorders; however, such association has not been studied in bipolar disorder (BD). We aimed to investigate the relationship between visuomotor coordination and social cognition in the euthymic stage of BD (euBD). Given the shared neurobiological underpinnings involving the dopaminergic system and corticostriatal circuitry, we hypothesized a positive correlation between social cognition and visuomotor coordination in euBD patients. Methods: 40 euBD patients and 59 healthy control (HC) participants underwent evaluation of social (Diagnostic Analysis of Nonverbal Accuracy 2-Taiwan version (DANVA-2-TW)), non-social cognitive function and visuomotor coordination. A subgroup of participants completed single-photon emission computed tomography for striatal dopamine transporter (DAT) availability assessment. Results: EuBD patients showed impaired nonverbal emotion recognition (ps ≤ 0.033) and poorer visuomotor coordination (ps < 0.003) compared to HC, with a positive correlation between these two abilities (r = 0.55, p < 0.01). However, after considering potential confounding factors, instead of visuomotor coordination, striatal DAT availability was a unique predictor of emotion recognition accuracy in euBD (beta = 0.33, p = 0.001). Conclusion: Our study result supported a functional association between social cognition and visuomotor coordination in euBD, with striatal dopaminergic dysfunction emerged as a crucial contributing factor in their interrelation.",
author = "Tsai, {Ying Tsung} and Chang, {Chih Yu} and Wu, {Cheng Ying} and Huang, {Yu Lien} and Chang, {Hui Hua} and Tsung-Hua Lu and Chang, {Wei Hung} and Chiu, {Nan Tsing} and Hsu, {Chia Fen} and Yen-Kuang Yang and Chen, {Po See} and Huai-Hsuan Tseng",
note = "Funding Information: This work was supported by the National Science and Technology Council, Taiwan ( MOST 106-2320-B-006-040 , MOST 107-2320-B-006-071 , MOST 107-2628-B-006-005- , MOST 108-2320-B-006-047-MY3 , MOST 108-2314-B-006-045 , MOST 108-2320-B-006-004- , MOST 108-2321-B-006-026-MY2 , MOST 108-2628-B-006-004- , MOST 109-2628-B-006-004- , and MOST 110-2314-B-006-061-MY3 ) and National Cheng Kung University Hospital ( NCKUH-10902014 ). The funding institutions had no further role in the study design, the collection, analysis, and interpretation of data, the writing of this paper, or the decision to submit it for publication. Funding Information: Supporting our hypothesis, there was a significant correlation between less accurate emotion recognition and poorer visuomotor coordination among euthymic BD patients. Such correlation may not be unique to BD. Co-occurrence of visuomotor and social cognitive deficits was also observed in several neuropsychiatric disorders. Growing evidence of social cognitive deficits is found in movement disorders like Parkinson's Disease, Huntington's disease and Tourette Syndrome (Eddy et al., 2018), while visuomotor deficits are increasingly recognized in psychiatric disorder characterized by social cognitive deficits, such as autism spectrum disorder (ASD) or Schizophrenia (Salgado-Pineda et al., 2005).This work was supported by the National Science and Technology Council, Taiwan (MOST 106-2320-B-006-040, MOST 107-2320-B-006-071, MOST 107-2628-B-006-005-, MOST 108-2320-B-006-047-MY3, MOST 108-2314-B-006-045, MOST 108-2320-B-006-004-, MOST 108-2321-B-006-026-MY2, MOST 108-2628-B-006-004-, MOST 109-2628-B-006-004-, and MOST 110-2314-B-006-061-MY3) and National Cheng Kung University Hospital (NCKUH-10902014). The funding institutions had no further role in the study design, the collection, analysis, and interpretation of data, the writing of this paper, or the decision to submit it for publication. Publisher Copyright: {\textcopyright} 2023",
year = "2023",
month = sep,
doi = "10.1016/j.jpsychires.2023.07.024",
language = "English",
volume = "165",
pages = "158--164",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
}
