Software-programmable continuous-flow multi-purpose lab-on-a-chip

Ahmed M. Amin, Raviraj Thakur, Seth Madren, Han Sheng Chuang, Mithuna Thottethodi, T. N. Vijaykumar, Steven T. Wereley, Stephen C. Jacobson

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Current lab-on-a-chip (LoC) devices are assay-specific and are custom-built for each single experiment. Performing an experiment requires scientists or engineers to go through the time-consuming process of designing, fabricating, and testing a chip before conducting the actual experiment. This prolonged cycle can take months to complete, increasing effort and cost and reducing productivity. Similarly, minor modifications to an assay protocol re-incur the overheads of the design cycle. In this paper, we develop a multi-purpose, software-programmable Lab-on-a-Chip (SPLoC), where the user simply writes or downloads a program for each experiment. We describe the components necessary to realize the SPLoC, which include a high-level programming language, an abstract instruction set, a runtime and control system, and a microfluidic device. We describe two key features of our high-level language compiler, and describe a novel variable-volume variable-ratio mixer. Finally, we demonstrate our SPLoC on four diverse, real-world assays.

Original languageEnglish
Pages (from-to)647-659
Number of pages13
JournalMicrofluidics and Nanofluidics
Volume15
Issue number5
DOIs
Publication statusPublished - 2013 Nov

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

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    Amin, A. M., Thakur, R., Madren, S., Chuang, H. S., Thottethodi, M., Vijaykumar, T. N., Wereley, S. T., & Jacobson, S. C. (2013). Software-programmable continuous-flow multi-purpose lab-on-a-chip. Microfluidics and Nanofluidics, 15(5), 647-659. https://doi.org/10.1007/s10404-013-1180-2