Solid-state synthesis of monocrystalline iron oxide nanoparticle based ferrofluid suitable for magnetic resonance imaging contrast application

Jun Lu, Shihe Yang, Ka Ming Ng, Chia Hao Su, Chen Sheng Yeh, Ya Na Wu, Dar Bin Shieh

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A new γ-Fe2O3 MION ferrofluid has been developed with a salt-assisted solid-state reaction. Characterizations show that the ferrofluid is composed of maghemite nanoparticles with a mean diameter of 2.7nm. Though the nanoparticles are ultrafine, they are well crystallized, with a saturation magnetization value of 34.7emug-1, making them suitable for MRI applications. In spite of the absence of any surfactant, the ferrofluid can be stable for more than 6 months. An in vitro cytotoxicity test revealed good biocompatibility of the maghemite nanoparticles, suggesting that they may be further explored for biomedical applications. NMR measurements revealed significantly reduced water proton relaxation times T1 and T 2. The MR images of the nanoparticles in aqueous dispersion were investigated using a 3T clinical MR imager. These preliminary experiments have demonstrated the potential of the as-synthesized ultrafine, cap-free maghemite MIONs in functional molecular imaging for biomedical research and clinical diagnosis.

Original languageEnglish
Article number017
Pages (from-to)5812-5820
Number of pages9
JournalNanotechnology
Volume17
Issue number23
DOIs
Publication statusPublished - 2006 Dec 14

Fingerprint

Magnetic fluids
Magnetic resonance
Iron oxides
Nanoparticles
Imaging techniques
Molecular imaging
Saturation magnetization
Cytotoxicity
Solid state reactions
Biocompatibility
Image sensors
Surface-Active Agents
Magnetic resonance imaging
Relaxation time
Protons
Surface active agents
Salts
Nuclear magnetic resonance
monocrystalline iron oxide nanoparticle
Water

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

@article{b92dfec2476147d0b5dc31558a173bed,
title = "Solid-state synthesis of monocrystalline iron oxide nanoparticle based ferrofluid suitable for magnetic resonance imaging contrast application",
abstract = "A new γ-Fe2O3 MION ferrofluid has been developed with a salt-assisted solid-state reaction. Characterizations show that the ferrofluid is composed of maghemite nanoparticles with a mean diameter of 2.7nm. Though the nanoparticles are ultrafine, they are well crystallized, with a saturation magnetization value of 34.7emug-1, making them suitable for MRI applications. In spite of the absence of any surfactant, the ferrofluid can be stable for more than 6 months. An in vitro cytotoxicity test revealed good biocompatibility of the maghemite nanoparticles, suggesting that they may be further explored for biomedical applications. NMR measurements revealed significantly reduced water proton relaxation times T1 and T 2. The MR images of the nanoparticles in aqueous dispersion were investigated using a 3T clinical MR imager. These preliminary experiments have demonstrated the potential of the as-synthesized ultrafine, cap-free maghemite MIONs in functional molecular imaging for biomedical research and clinical diagnosis.",
author = "Jun Lu and Shihe Yang and Ng, {Ka Ming} and Su, {Chia Hao} and Yeh, {Chen Sheng} and Wu, {Ya Na} and Shieh, {Dar Bin}",
year = "2006",
month = "12",
day = "14",
doi = "10.1088/0957-4484/17/23/017",
language = "English",
volume = "17",
pages = "5812--5820",
journal = "Nanotechnology",
issn = "0957-4484",
publisher = "IOP Publishing Ltd.",
number = "23",

}

Solid-state synthesis of monocrystalline iron oxide nanoparticle based ferrofluid suitable for magnetic resonance imaging contrast application. / Lu, Jun; Yang, Shihe; Ng, Ka Ming; Su, Chia Hao; Yeh, Chen Sheng; Wu, Ya Na; Shieh, Dar Bin.

In: Nanotechnology, Vol. 17, No. 23, 017, 14.12.2006, p. 5812-5820.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Solid-state synthesis of monocrystalline iron oxide nanoparticle based ferrofluid suitable for magnetic resonance imaging contrast application

AU - Lu, Jun

AU - Yang, Shihe

AU - Ng, Ka Ming

AU - Su, Chia Hao

AU - Yeh, Chen Sheng

AU - Wu, Ya Na

AU - Shieh, Dar Bin

PY - 2006/12/14

Y1 - 2006/12/14

N2 - A new γ-Fe2O3 MION ferrofluid has been developed with a salt-assisted solid-state reaction. Characterizations show that the ferrofluid is composed of maghemite nanoparticles with a mean diameter of 2.7nm. Though the nanoparticles are ultrafine, they are well crystallized, with a saturation magnetization value of 34.7emug-1, making them suitable for MRI applications. In spite of the absence of any surfactant, the ferrofluid can be stable for more than 6 months. An in vitro cytotoxicity test revealed good biocompatibility of the maghemite nanoparticles, suggesting that they may be further explored for biomedical applications. NMR measurements revealed significantly reduced water proton relaxation times T1 and T 2. The MR images of the nanoparticles in aqueous dispersion were investigated using a 3T clinical MR imager. These preliminary experiments have demonstrated the potential of the as-synthesized ultrafine, cap-free maghemite MIONs in functional molecular imaging for biomedical research and clinical diagnosis.

AB - A new γ-Fe2O3 MION ferrofluid has been developed with a salt-assisted solid-state reaction. Characterizations show that the ferrofluid is composed of maghemite nanoparticles with a mean diameter of 2.7nm. Though the nanoparticles are ultrafine, they are well crystallized, with a saturation magnetization value of 34.7emug-1, making them suitable for MRI applications. In spite of the absence of any surfactant, the ferrofluid can be stable for more than 6 months. An in vitro cytotoxicity test revealed good biocompatibility of the maghemite nanoparticles, suggesting that they may be further explored for biomedical applications. NMR measurements revealed significantly reduced water proton relaxation times T1 and T 2. The MR images of the nanoparticles in aqueous dispersion were investigated using a 3T clinical MR imager. These preliminary experiments have demonstrated the potential of the as-synthesized ultrafine, cap-free maghemite MIONs in functional molecular imaging for biomedical research and clinical diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=33846050483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846050483&partnerID=8YFLogxK

U2 - 10.1088/0957-4484/17/23/017

DO - 10.1088/0957-4484/17/23/017

M3 - Article

AN - SCOPUS:33846050483

VL - 17

SP - 5812

EP - 5820

JO - Nanotechnology

JF - Nanotechnology

SN - 0957-4484

IS - 23

M1 - 017

ER -