Some physical factors in toxicological assessment tests

V. H. Freed, C. T. Chiou, D. Schmedding, R. Kohnert

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Many thousand organic compounds are in common use and new ones introduced daily. With many of these materials, little is known about their toxic hazard. For years scientists have been investigating the relation of structure and properties to biological activity. Among the factors relating to toxicity are bioaccumulation and persistence in the organism. In this study, the relations of partition coefficient and solubility to bioaccumulation of some organochlorine compounds was investigated as was also the reactivity of several organophosphates. The work adds confirmation to the relation of molecular paramters to penetration, accumulation, and persistence in toxic action.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalEnvironmental Health Perspectives
VolumeVol. 30
Publication statusPublished - 1979

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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