“Spade sign” and inflammation/fibrosis limited to the upper and mid-dermis as the pathognomonic features of acne keloidalis

An Yu Cheng, Chaw Ning Lee, Fu Nien Hsieh, Tzu Kun Lo, Hsin Yu Huang, Chao Kai Hsu, Julia Yu Yun Lee, Chao Chun Yang

Research output: Contribution to journalArticle

Abstract

Acne keloidalis (AK) is one of the primary cicatricial alopecias and predominantly affects men of African descent. Reports in Asians are scant. This study aimed to retrospectively review the clinical and histopathological features of AK patients in southern Taiwan and identify the pathognomonic features of AK. There were 15 patients with histopathologically confirmed AK in National Cheng Kung University Hospital between 1988 and 2018. The median onset age was 24 years (range, 14–71). The male : female ratio was 14:1. In the acute stage of AK, the lymphocytic and neutrophilic peri-infundibular inflammatory infiltrates with microabscess formation and edema corresponded to the clinical finding of isolated papules or pustules. Subsequently, the inflammatory infiltrates involved the mid-dermis and the isthmus of hair follicles. The “spade sign”, a thin and dilated space resembling the shape of a balloon or spade symbol of playing cards at the level of lower isthmus, was identified in eight biopsies from five patients and may be a pathognomonic sign in the subacute stage of AK. At the chronic stage, the segments of hair shafts remained in the upper to mid-dermis and induced chronic inflammation and extensive fibrosis, resulting in the clinical keloid-like appearance. The restriction of inflammation and fibrosis in the upper to mid-dermis was another unique and pathognomonic feature of AK.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalJournal of Dermatology
Volume47
Issue number1
DOIs
Publication statusPublished - 2020 Jan 1

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Acne Keloid
Dermis
Fibrosis
Inflammation
Keloid
Hair Follicle
Alopecia
Taiwan
Age of Onset
Hair
Edema
Biopsy

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

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abstract = "Acne keloidalis (AK) is one of the primary cicatricial alopecias and predominantly affects men of African descent. Reports in Asians are scant. This study aimed to retrospectively review the clinical and histopathological features of AK patients in southern Taiwan and identify the pathognomonic features of AK. There were 15 patients with histopathologically confirmed AK in National Cheng Kung University Hospital between 1988 and 2018. The median onset age was 24 years (range, 14–71). The male : female ratio was 14:1. In the acute stage of AK, the lymphocytic and neutrophilic peri-infundibular inflammatory infiltrates with microabscess formation and edema corresponded to the clinical finding of isolated papules or pustules. Subsequently, the inflammatory infiltrates involved the mid-dermis and the isthmus of hair follicles. The “spade sign”, a thin and dilated space resembling the shape of a balloon or spade symbol of playing cards at the level of lower isthmus, was identified in eight biopsies from five patients and may be a pathognomonic sign in the subacute stage of AK. At the chronic stage, the segments of hair shafts remained in the upper to mid-dermis and induced chronic inflammation and extensive fibrosis, resulting in the clinical keloid-like appearance. The restriction of inflammation and fibrosis in the upper to mid-dermis was another unique and pathognomonic feature of AK.",
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“Spade sign” and inflammation/fibrosis limited to the upper and mid-dermis as the pathognomonic features of acne keloidalis. / Cheng, An Yu; Lee, Chaw Ning; Hsieh, Fu Nien; Lo, Tzu Kun; Huang, Hsin Yu; Hsu, Chao Kai; Lee, Julia Yu Yun; Yang, Chao Chun.

In: Journal of Dermatology, Vol. 47, No. 1, 01.01.2020, p. 41-46.

Research output: Contribution to journalArticle

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AU - Cheng, An Yu

AU - Lee, Chaw Ning

AU - Hsieh, Fu Nien

AU - Lo, Tzu Kun

AU - Huang, Hsin Yu

AU - Hsu, Chao Kai

AU - Lee, Julia Yu Yun

AU - Yang, Chao Chun

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