TY - JOUR
T1 - Spatial transcriptomics in human skin research
AU - Tekkela, Stavroula
AU - Theocharidis, Georgios
AU - McGrath, John A.
AU - Onoufriadis, Alexandros
N1 - Funding Information:
Stavroula Tekkela and Alexandros Onoufriadis have been supported from EB Research Partnership. Georgios Theocharidis was supported by the National Rongxiang Xu Foundation at Harvard Medical School.
Funding Information:
Original studies using spatial transcriptomics by the senior author and colleagues have been supported by funding from EB Research Partnership. This work was supported by the National Institute for Health Research Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London and by the National Rongxiang Xu Foundation at Harvard Medical School.
Publisher Copyright:
© 2023 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Spatial transcriptomics is a revolutionary technique that enables researchers to characterise tissue architecture and localisation of gene expression. A plethora of technologies that map gene expression are currently being developed, aiming to facilitate spatially resolved, high-dimensional assessment of gene transcription in the context of human skin research. Knowing which gene is expressed by which cell and in which location within skin, facilitates understanding of skin function and dysfunction in both health and disease. In this review, we summarise the available spatial transcriptomic methods and we describe their application to a broad spectrum of dermatological diseases.
AB - Spatial transcriptomics is a revolutionary technique that enables researchers to characterise tissue architecture and localisation of gene expression. A plethora of technologies that map gene expression are currently being developed, aiming to facilitate spatially resolved, high-dimensional assessment of gene transcription in the context of human skin research. Knowing which gene is expressed by which cell and in which location within skin, facilitates understanding of skin function and dysfunction in both health and disease. In this review, we summarise the available spatial transcriptomic methods and we describe their application to a broad spectrum of dermatological diseases.
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U2 - 10.1111/exd.14827
DO - 10.1111/exd.14827
M3 - Review article
C2 - 37150587
AN - SCOPUS:85158133210
SN - 0906-6705
VL - 32
SP - 731
EP - 739
JO - Experimental Dermatology
JF - Experimental Dermatology
IS - 6
ER -
