Species distribution and antifungal susceptibility of blood Candida isolates at a tertiary hospital in southern Taiwan, 1999-2006

Po-Lin Chen, Hsiu Jung Lo, Chi Jung Wu, Hsin Chun Lee, Chia-Ming Chang, Nan-Yao Lee, An Huei Wang, Wen Liang Lin, Nai-Ying Ko, Ching Chi Lee, Wen-Chien Ko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to evaluate the incidence of candidaemia, consumption of fluconazole and susceptibility of blood Candida isolates at a tertiary hospital. From January 1999 to September 2006, all candidaemic episodes were identified and available strains were evaluated for the susceptibilities of antifungal agents. Annual defined daily doses of antifungal agents were collected. There had been 909 Candida isolates detected from the bloodstream of 843 patients during the study period. Among them, 740 isolates were available for the susceptibilities of antifungal agents. The incidence density of candidaemia was 28 episodes per 10000 patient-days. Species distribution of 909 isolates did not vary annually, but varied greatly in the units of the hospital. Candida parapsilosis was the more prominent (30.1%) isolate in the paediatric units, where C. tropicalis and C. glabrata were less common (12.3% and 1.4% respectively). Resistance rates for itraconazole, fluconazole and voriconazole were 6.9%, 3.8% and 3.8% respectively. There were 25 (3.4%) isolates resistant to amphotericin-B. Although fluconazole usage increased over time (r2=0.45; P=0.07), fluconazole resistance did not increase accordingly (P=0.33). In our institution in which the incidence of candidaemia was high, fluconazole resistance among blood Candida isolates remained rare.

Original languageEnglish
JournalMycoses
Volume54
Issue number4
DOIs
Publication statusPublished - 2011 Jul 1

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Fluconazole
Taiwan
Candida
Tertiary Care Centers
Candidemia
Antifungal Agents
Incidence
Hospital Units
Itraconazole
Amphotericin B
Pediatrics

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

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title = "Species distribution and antifungal susceptibility of blood Candida isolates at a tertiary hospital in southern Taiwan, 1999-2006",
abstract = "The aim of this study was to evaluate the incidence of candidaemia, consumption of fluconazole and susceptibility of blood Candida isolates at a tertiary hospital. From January 1999 to September 2006, all candidaemic episodes were identified and available strains were evaluated for the susceptibilities of antifungal agents. Annual defined daily doses of antifungal agents were collected. There had been 909 Candida isolates detected from the bloodstream of 843 patients during the study period. Among them, 740 isolates were available for the susceptibilities of antifungal agents. The incidence density of candidaemia was 28 episodes per 10000 patient-days. Species distribution of 909 isolates did not vary annually, but varied greatly in the units of the hospital. Candida parapsilosis was the more prominent (30.1{\%}) isolate in the paediatric units, where C. tropicalis and C. glabrata were less common (12.3{\%} and 1.4{\%} respectively). Resistance rates for itraconazole, fluconazole and voriconazole were 6.9{\%}, 3.8{\%} and 3.8{\%} respectively. There were 25 (3.4{\%}) isolates resistant to amphotericin-B. Although fluconazole usage increased over time (r2=0.45; P=0.07), fluconazole resistance did not increase accordingly (P=0.33). In our institution in which the incidence of candidaemia was high, fluconazole resistance among blood Candida isolates remained rare.",
author = "Po-Lin Chen and Lo, {Hsiu Jung} and Wu, {Chi Jung} and Lee, {Hsin Chun} and Chia-Ming Chang and Nan-Yao Lee and Wang, {An Huei} and Lin, {Wen Liang} and Nai-Ying Ko and Lee, {Ching Chi} and Wen-Chien Ko",
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Species distribution and antifungal susceptibility of blood Candida isolates at a tertiary hospital in southern Taiwan, 1999-2006. / Chen, Po-Lin; Lo, Hsiu Jung; Wu, Chi Jung; Lee, Hsin Chun; Chang, Chia-Ming; Lee, Nan-Yao; Wang, An Huei; Lin, Wen Liang; Ko, Nai-Ying; Lee, Ching Chi; Ko, Wen-Chien.

In: Mycoses, Vol. 54, No. 4, 01.07.2011.

Research output: Contribution to journalArticle

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T1 - Species distribution and antifungal susceptibility of blood Candida isolates at a tertiary hospital in southern Taiwan, 1999-2006

AU - Chen, Po-Lin

AU - Lo, Hsiu Jung

AU - Wu, Chi Jung

AU - Lee, Hsin Chun

AU - Chang, Chia-Ming

AU - Lee, Nan-Yao

AU - Wang, An Huei

AU - Lin, Wen Liang

AU - Ko, Nai-Ying

AU - Lee, Ching Chi

AU - Ko, Wen-Chien

PY - 2011/7/1

Y1 - 2011/7/1

N2 - The aim of this study was to evaluate the incidence of candidaemia, consumption of fluconazole and susceptibility of blood Candida isolates at a tertiary hospital. From January 1999 to September 2006, all candidaemic episodes were identified and available strains were evaluated for the susceptibilities of antifungal agents. Annual defined daily doses of antifungal agents were collected. There had been 909 Candida isolates detected from the bloodstream of 843 patients during the study period. Among them, 740 isolates were available for the susceptibilities of antifungal agents. The incidence density of candidaemia was 28 episodes per 10000 patient-days. Species distribution of 909 isolates did not vary annually, but varied greatly in the units of the hospital. Candida parapsilosis was the more prominent (30.1%) isolate in the paediatric units, where C. tropicalis and C. glabrata were less common (12.3% and 1.4% respectively). Resistance rates for itraconazole, fluconazole and voriconazole were 6.9%, 3.8% and 3.8% respectively. There were 25 (3.4%) isolates resistant to amphotericin-B. Although fluconazole usage increased over time (r2=0.45; P=0.07), fluconazole resistance did not increase accordingly (P=0.33). In our institution in which the incidence of candidaemia was high, fluconazole resistance among blood Candida isolates remained rare.

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