Sphingomonas paucimobilis Bacteremia in Humans: 16 Case Reports and a Literature Review

Jiun Nong Lin, Chung Hsu Lai, Yen Hsu Chen, Hsing Lin Lin, Chun Kai Huang, Wei Fang Chen, Jiun-Ling Wang, Hsing Chun Chung, Shiou Haur Liang, Hsi Hsun Lin

Research output: Contribution to journalArticle

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Abstract

Background/Purpose: Sphingomonas paucimobilis is a glucose-nonfermenting Gram-negative bacillus that is widely distributed in both natural environment and hospitals. Various infections in humans have been reported, but most have been limited to sporadic case reports. The aim of this study was to describe the clinical characteristics and manifestations of S. paucimobilis bacteremia. We also reviewed the literature on S. paucimobilis bacteremia. Methods: Cases of S. paucimobilis bacteremia were identified retrospectively at a university-affiliated hospital in Taiwan. In addition, relevant case reports were identified through PubMed and reviewed. Results: From April 2004 to April 2008, 42 cases of S. paucimobilis bacteremia were identified in this study. Among them, 16 cases were identified from E-Da hospital, Kaohsiung, Taiwan and 26 cases from the literature review. The median age of patients was 48.5 years and 57.1% were male. The most common comorbidities included malignancy (57.1%), immunosuppressant use (40.5%), and diabetic mellitus (11.9%). Hospital-acquired bacteremia accounted for 69.0% of infections. Primary bacteremia and catheter-related bloodstream infection were found in 35.7% and 33.3% respectively. The most effective antibiotics were fluoroquinolones, carbapenems, and β-lactam/β-lactamase inhibitor combinations. All 42 patients survived the S. paucimobilis bacteremic episodes, but three patients experienced septic shock. Conclusion: S. paucimobilis can cause infections in healthy as well as immunocompromised individuals. Although it is an organism of low clinical virulence, infection caused by S. paucimobilis can lead to septic shock. Further clinical research is required to characterize this infection.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Volume43
Issue number1
DOIs
Publication statusPublished - 2010 Feb 1

Fingerprint

Sphingomonas
Bacteremia
Infection
Septic Shock
Taiwan
Catheter-Related Infections
Lactams
Carbapenems
Fluoroquinolones
Immunosuppressive Agents
PubMed
Bacillus
Virulence
Comorbidity
Anti-Bacterial Agents
Glucose
Research

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lin, Jiun Nong ; Lai, Chung Hsu ; Chen, Yen Hsu ; Lin, Hsing Lin ; Huang, Chun Kai ; Chen, Wei Fang ; Wang, Jiun-Ling ; Chung, Hsing Chun ; Liang, Shiou Haur ; Lin, Hsi Hsun. / Sphingomonas paucimobilis Bacteremia in Humans : 16 Case Reports and a Literature Review. In: Journal of Microbiology, Immunology and Infection. 2010 ; Vol. 43, No. 1. pp. 35-42.
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title = "Sphingomonas paucimobilis Bacteremia in Humans: 16 Case Reports and a Literature Review",
abstract = "Background/Purpose: Sphingomonas paucimobilis is a glucose-nonfermenting Gram-negative bacillus that is widely distributed in both natural environment and hospitals. Various infections in humans have been reported, but most have been limited to sporadic case reports. The aim of this study was to describe the clinical characteristics and manifestations of S. paucimobilis bacteremia. We also reviewed the literature on S. paucimobilis bacteremia. Methods: Cases of S. paucimobilis bacteremia were identified retrospectively at a university-affiliated hospital in Taiwan. In addition, relevant case reports were identified through PubMed and reviewed. Results: From April 2004 to April 2008, 42 cases of S. paucimobilis bacteremia were identified in this study. Among them, 16 cases were identified from E-Da hospital, Kaohsiung, Taiwan and 26 cases from the literature review. The median age of patients was 48.5 years and 57.1{\%} were male. The most common comorbidities included malignancy (57.1{\%}), immunosuppressant use (40.5{\%}), and diabetic mellitus (11.9{\%}). Hospital-acquired bacteremia accounted for 69.0{\%} of infections. Primary bacteremia and catheter-related bloodstream infection were found in 35.7{\%} and 33.3{\%} respectively. The most effective antibiotics were fluoroquinolones, carbapenems, and β-lactam/β-lactamase inhibitor combinations. All 42 patients survived the S. paucimobilis bacteremic episodes, but three patients experienced septic shock. Conclusion: S. paucimobilis can cause infections in healthy as well as immunocompromised individuals. Although it is an organism of low clinical virulence, infection caused by S. paucimobilis can lead to septic shock. Further clinical research is required to characterize this infection.",
author = "Lin, {Jiun Nong} and Lai, {Chung Hsu} and Chen, {Yen Hsu} and Lin, {Hsing Lin} and Huang, {Chun Kai} and Chen, {Wei Fang} and Jiun-Ling Wang and Chung, {Hsing Chun} and Liang, {Shiou Haur} and Lin, {Hsi Hsun}",
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Lin, JN, Lai, CH, Chen, YH, Lin, HL, Huang, CK, Chen, WF, Wang, J-L, Chung, HC, Liang, SH & Lin, HH 2010, 'Sphingomonas paucimobilis Bacteremia in Humans: 16 Case Reports and a Literature Review', Journal of Microbiology, Immunology and Infection, vol. 43, no. 1, pp. 35-42. https://doi.org/10.1016/S1684-1182(10)60005-9

Sphingomonas paucimobilis Bacteremia in Humans : 16 Case Reports and a Literature Review. / Lin, Jiun Nong; Lai, Chung Hsu; Chen, Yen Hsu; Lin, Hsing Lin; Huang, Chun Kai; Chen, Wei Fang; Wang, Jiun-Ling; Chung, Hsing Chun; Liang, Shiou Haur; Lin, Hsi Hsun.

In: Journal of Microbiology, Immunology and Infection, Vol. 43, No. 1, 01.02.2010, p. 35-42.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sphingomonas paucimobilis Bacteremia in Humans

T2 - 16 Case Reports and a Literature Review

AU - Lin, Jiun Nong

AU - Lai, Chung Hsu

AU - Chen, Yen Hsu

AU - Lin, Hsing Lin

AU - Huang, Chun Kai

AU - Chen, Wei Fang

AU - Wang, Jiun-Ling

AU - Chung, Hsing Chun

AU - Liang, Shiou Haur

AU - Lin, Hsi Hsun

PY - 2010/2/1

Y1 - 2010/2/1

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