Spinal adenosine modulates capsaicin-induced depressor reflex

Involvement of adenosine A2 receptor

Jwu Maw Yang, Sheng-Nan Wu, Ing Jun Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

1. 1. The depressor responses to i.a. and i.v. injection of capsaicin (CAP) were blocked following intrathecal (i.t.) perfusion of [d-Pro2, d-Trp7,9] substance P, a specific substance P antagonist. This confirmed that the CAP-elicited depressor reflex is mediated by substance P-containing afferent fibres. 2. 2. The regulatory roles of spinal adenosine in the CAP-evoked substance P release and the possible involvement of adenosine A2 receptors were analyzed by analyzing the changes in cardiovascular responses to i.a. and i.v. injection of CAP after various pretreatments with adenosine agonists and antagonists, administered subcutaneously or intrathecally.

Original languageEnglish
Pages (from-to)961-970
Number of pages10
JournalGeneral Pharmacology
Volume24
Issue number4
DOIs
Publication statusPublished - 1993 Jan 1

Fingerprint

Adenosine A2 Receptors
Capsaicin
Substance P
Adenosine
Reflex
Injections
Perfusion

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

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title = "Spinal adenosine modulates capsaicin-induced depressor reflex: Involvement of adenosine A2 receptor",
abstract = "1. 1. The depressor responses to i.a. and i.v. injection of capsaicin (CAP) were blocked following intrathecal (i.t.) perfusion of [d-Pro2, d-Trp7,9] substance P, a specific substance P antagonist. This confirmed that the CAP-elicited depressor reflex is mediated by substance P-containing afferent fibres. 2. 2. The regulatory roles of spinal adenosine in the CAP-evoked substance P release and the possible involvement of adenosine A2 receptors were analyzed by analyzing the changes in cardiovascular responses to i.a. and i.v. injection of CAP after various pretreatments with adenosine agonists and antagonists, administered subcutaneously or intrathecally.",
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Spinal adenosine modulates capsaicin-induced depressor reflex : Involvement of adenosine A2 receptor. / Yang, Jwu Maw; Wu, Sheng-Nan; Chen, Ing Jun.

In: General Pharmacology, Vol. 24, No. 4, 01.01.1993, p. 961-970.

Research output: Contribution to journalArticle

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