Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats

Jann Inn Tzeng, Chong Chi Chiu, Jhi Joung Wang, Ching Hsia Hung, Yu Wen Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: The aim of this experiment was mainly to examine the effects of intrathecally injected doxylamine and triprolidine, two antihistamine drugs spinal motor and sensory functions. Methods: After intrathecally injecting the rats with five different doses, the dose—response curves of spinal sensory and motor block with doxylamine and triprolidine were constructed. In comparison with the local anaesthetic mepivacaine, the quality and duration of spinal anaesthesia with doxylamine or triprolidine were conducted. Key findings: Doxylamine, mepivacaine and triprolidine elicited spinal motor and sensory (nociception and proprioception) blockades in a dose-dependent fashion. On the ED50 (50% effective dose) basis, the rank order of drug potency was triprolidine > mepivacaine > doxylamine (P < 0.05) at provoking spinal motor, proprioceptive and nociceptive blockades. On the equianaesthetic doses (ED25, ED50 and ED75), the duration of spinal anaesthesia with doxylamine was longer (P < 0.01) than that with mepivacaine or triprolidine. Moreover, doxylamine or triprolidine displayed greater potency (ED50) (P < 0.05) and duration (P < 0.05) of sensory block over motor block. Conclusions: Doxylamine or triprolidine produces a dose-dependent effect of spinal motor and sensory block. Triprolidine with a better nociception-selective action over motor block has a better potency than mepivacaine or doxylamine. Doxylamine and triprolidine produce longer durations than mepivacaine.

Original languageEnglish
Pages (from-to)1654-1661
Number of pages8
JournalJournal of Pharmacy and Pharmacology
Volume70
Issue number12
DOIs
Publication statusPublished - 2018 Dec

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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