Spread of hepatitis E virus among different-aged pigs: Two-year survey in Taiwan

Jaw Ching Wu, Chuan Mu Chen, Tzen-Yuh Chiang, Wen Hsuan Tsai, Wen Juei Jeng, I. Jane Sheen, Chen Chun Lin, Xiang Jin Meng

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97 Citations (Scopus)

Abstract

Swine are reservoirs of hepatitis E virus (HEV). In this study, a 2-year survey of HEV in feces and sera of swine was conducted to determine if: 1) HEV has circulated among pigs for some time in Taiwan; 2) the spread of HEV among different-aged pigs; and 3) there exists HEV strains possibly imported through trading. From 1998-2000, 521 serum samples and 54 fecal specimens from pigs were examined by reverse transcription polymerase chain reaction. None of the 11 pigs in suckling stage (<2 months) were serum HEV RNA positive. The highest viremia rate (4.5%) was in pigs of 2 months age, followed by 1.2% and 1.8% in pigs of growing (3-4 months) and finishing stages (5-6 months), and none in pigs older than 6 months. Viremia showed little variation in different years and areas. None of the 20 fecal samples from pigs in suckling stage were HEV RNA positive, whereas 9% of the 34 samples from pigs in growing or finishing stages were positive. Most swine HEV isolates in Taiwan clustered within the genotype 4, whereas the three HEV isolates cloned from pigs imported recently from the U.S. belonged to the genotype 3 HEV in the U.S. The results suggest that HEV may infect pigs at an early growing stage and spread unnoticed amonq pigs and possibly across countries through trading.

Original languageEnglish
Pages (from-to)488-492
Number of pages5
JournalJournal of Medical Virology
Volume66
Issue number4
DOIs
Publication statusPublished - 2002 Mar 19

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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