Stability of curcumin in buffer solutions and characterization of its degradation products

Ying Jan Wang, Min Hsiung Pan, Ann Lii Cheng, Liang In Lin, Yuan Soon Ho, Chang Yao Hsieh, Jen Kun Lin

Research output: Contribution to journalArticlepeer-review

1163 Citations (Scopus)

Abstract

The degradation kinetics of curcumin under various pH conditions and the stability of curcumin in physiological matrices were investigated. When curcumin was incubated in 0.1 M phosphate buffer and serum-free medium, pH 7.2 at 37°C, about 90% decomposed within 30 min. A series of pH conditions ranging from 3 to 10 were tested and the result showed that decomposition was pH-dependent and occurred faster at neutral-basic conditions. It is more stable in cell culture medium containing 10% fetal calf serum and in human blood; less than 20% of curcumin decomposed within 1 h, and after incubation for 8 h, about 50% of curcumin is still remained. Trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal was predicted as major degradation product and vanillin, ferulic acid, feruloyl methane were identified as minor degradation products. The amount of vanillin increased with incubation time.

Original languageEnglish
Pages (from-to)1867-1876
Number of pages10
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume15
Issue number12
DOIs
Publication statusPublished - 1997 Aug

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Stability of curcumin in buffer solutions and characterization of its degradation products'. Together they form a unique fingerprint.

Cite this