Stable ethosome-like catanionic vesicles for transdermal hydrophilic drug delivery with predictable encapsulation efficiency

Chun Wei Wang, Ming Chen Chuang, Chieh Yi Chang, Chien Hsiang Chang, Yu Min Yang

Research output: Contribution to journalArticlepeer-review


Lipid-like pseudo-double-chained catanionic surfactants have emerged as the attractive materials to prepare potential vesicular carriers in drug and gene delivery applications. In particular, the semi-spontaneous process has been developed to fabricate ethosome-like catanionic vesicles for the transdermal drug delivery. In this work, Arbutin (a water-soluble drug) encapsulation efficiency of ethosome-like catanionic vesicles fabricated from decyltrimethylammonium-tetradecylsulfate (DeTMA-TS, CH3 (CH2 )9 N(CH3 )3-CH3 (CH2 )13 SO4 ) and decyltrimethylammonium-dodecylsulfate (DeTMA-DS, CH3 (CH2 )9 N(CH3 )3-CH3(CH2)11SO4) with various amounts of ethanol and cholesterol in tris buffer solution was experimentally determined. A simple unilamellar vesicle (ULV) model, resulting in the theoretical encapsulation efficiency within ±10% error for most vesicle compositions, was also developed. Such agreement indirectly confirmed the formation of unilamellar vesicles by the preparation method. Stable ethosome-like catanionic vesicles by using catanionic surfactants with the aid of suitable amounts of ethanol and cholesterol, which led to polydispersity index (PDI) values of vesicle size distribution less than 0.3, were successfully prepared and their hydrophilic drug encapsulation efficiencies can be accurately predicted. Furthermore, the linear correlations of the trap volume ratio with both vesicle size and concentration of the extra added CHOL also provide important guidelines for controlling the drug loading of ethosome-like catanionic vesicles. The accomplishments reached for the novel vesicles are useful for developing their transdermal drug delivery applications.

Original languageEnglish
Pages (from-to)1391-1401
Number of pages11
JournalJournal of oleo science
Issue number10
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)


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