Stable isotope dimethyl labelling for quantitative proteomics and beyond

Jue Liang Hsu, Shu Hui Chen

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


Stable-isotope reductive dimethylation, a costeffective, simple, robust, reliable and easy-tomultiplex labelling method, is widely applied to quantitative proteomics using liquid chromatography-mass spectrometry. This review focuses on biological applications of stable-isotope dimethyl labelling for a large-scale comparative analysis of protein expression and post-translational modifications based on its unique properties of the labelling chemistry. Some other applications of the labelling method for sample preparation and mass spectrometry-based protein identification and characterization are also summarized.

Original languageEnglish
Article number20150364
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Issue number2079
Publication statusPublished - 2016 Oct 28

All Science Journal Classification (ASJC) codes

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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