Statistical analysis of nucleotide sequences of the hemagglutinin gene of human influenza A viruses

Yasuo Ina, Takashi Gojobori

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83 Citations (Scopus)

Abstract

To examine whether positive selection operates on the hemagglutinin 1 (HA1) gene of human influenza A viruses (H1 subtype), 21 nucleotide sequences of the HA1 gene were statistically analyzed. The nucleotide sequences were divided into antigenic and nonantigenic sites. The nucleotide diversities for antigenic and nonantigenic sites of the HA1 gene were computed at synonymous and nonsynonymous sites separately. For nonantigenic sites, the nucleotide diversities were larger at synonymous sites than at nonsynonymous sites. This is consistent with the neutral theory of molecular evolution. For antigenic sites, however, the nucleotide diversities at nonsynonymous sites were larger than those at synonymous sites. These results suggest that positive selection operates on antigenic sites of the HA1 gene of human influenza A viruses (H1 subtype).

Original languageEnglish
Pages (from-to)8388-8392
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number18
DOIs
Publication statusPublished - 1994 Aug 30

All Science Journal Classification (ASJC) codes

  • General

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