STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13

David P. Andrew, Ming-Shi Chang, Jennifer McNinch, Scott T. Wathen, Marynette Rihanek, Julia Tseng, Jason P. Spellberg, G. Elias Chester

Research output: Contribution to journalArticlepeer-review

244 Citations (Scopus)

Abstract

STCP-1 stimulated T cell chemoattractant protein-1 (STCP-1) (macrophage- derived chemokine; MDC), a recently described CC chemokine for chronically activated T lymphocytes, was found to act specifically on a subset of memory CD4 lymphocytes that displayed a Th2 cytokine profile. Also, STCP-1, thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in vitro derived Th2 lymphocytes, while IP-10 (IFN-γ- inducible 10-kDa protein) showed some preference for Th1 lymphocytes. The corresponding receptors for eotaxin, TARC, and IP-10 are also differentially expressed on Th1 and Th2 lymphocytes. In desensitization Ca flux experiments, TARC and STCP-1 bound to a common receptor and therefore at least one chemokine receptor for STCP-1 is CCR4. STCP-1 expression is restricted to immune cells. Dendritic cells, B cells, and macrophages produce STCP-1 constitutively, while NK cells, monocytes, and CD4 lymphocytes produce STCP- 1 upon appropriate stimulation. Production of STCP-1 is positively modulated by Th2 cytokines IL-4 and IL-13 but inhibited by IL-10.

Original languageEnglish
Pages (from-to)5027-5038
Number of pages12
JournalJournal of Immunology
Volume161
Issue number9
Publication statusPublished - 1998 Nov 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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