Stem cell transplantation therapy in Parkinson’s disease

Mu Hui Fu; Chia Ling Li; Hsiu Lien Lin; Pei Chun Chen; Marcus J. Calkins; Yu Fan Chang; Pei Hsun Cheng; Shang Hsun Yang

doi:10.1186/s40064-015-1400-1

Stem cell transplantation therapy in Parkinson’s disease

Mu Hui Fu, Chia Ling Li, Hsiu Lien Lin, Pei Chun Chen, Marcus J. Calkins, Yu Fan Chang, Pei Hsun Cheng, Shang Hsun Yang

Department of Physiology

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease.

Original language	English
Article number	597
Journal	SpringerPlus
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/s40064-015-1400-1
Publication status	Published - 2015 Dec 1

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10.1186/s40064-015-1400-1

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title = "Stem cell transplantation therapy in Parkinson{\textquoteright}s disease",

abstract = "Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson{\textquoteright}s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson{\textquoteright}s disease.",

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AU - Fu, Mu Hui

AU - Li, Chia Ling

AU - Lin, Hsiu Lien

AU - Chen, Pei Chun

AU - Calkins, Marcus J.

AU - Chang, Yu Fan

AU - Cheng, Pei Hsun

AU - Yang, Shang Hsun

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease.

AB - Ineffective therapeutic treatments and inadequate repair ability in the central nervous system are disturbing problems for several neurological diseases. Fortunately, the development of clinically applicable populations of stem cells has provided an avenue to overcome the failure of endogenous repair systems and substitute new cells into the damaged brain. However, there are still several existing obstacles to translating into clinical application. Here we review the stem-cell based therapies for Parkinson’s disease and discuss the potential advantages and drawbacks. We hope this review may provide suggestions for viable strategies to overcome the current technical and biological issues associated with the application of stem cells in Parkinson’s disease.

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Stem cell transplantation therapy in Parkinson’s disease

Abstract

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