Stem cells in the lung parenchyma and prospects for lung injury therapy

C. C. Yen, S. H. Yang, C. Y. Lin, C. M. Chen

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Until recently, it was thought that only embryonic stem cells were pluripotent and that adult stem cells were restricted in their differentiative and regenerative potential to become the tissues in which they reside. However, the discovery that adult stem cells in one tissue can contribute to the formation of other tissues, especially after injury or cell damage, implies that stem cells have developmental plasticity. For example, haematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) from bone marrow can be used to regenerate diverse tissues at distant sites, including the lung. This article reviews the character of stem cells in the lung parenchyma and focuses on the potential uses of adult stem cells in research of lung injury and lung disease therapies.

Original languageEnglish
Pages (from-to)310-319
Number of pages10
JournalEuropean Journal of Clinical Investigation
Volume36
Issue number5
DOIs
Publication statusPublished - 2006 May 1

Fingerprint

Lung Injury
Stem cells
Stem Cells
Lung
Adult Stem Cells
Tissue
Stem Cell Research
Pluripotent Stem Cells
Therapeutics
Embryonic Stem Cells
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Lung Diseases
Bone Marrow
Pulmonary diseases
Wounds and Injuries
Plasticity
Bone
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry

Cite this

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Stem cells in the lung parenchyma and prospects for lung injury therapy. / Yen, C. C.; Yang, S. H.; Lin, C. Y.; Chen, C. M.

In: European Journal of Clinical Investigation, Vol. 36, No. 5, 01.05.2006, p. 310-319.

Research output: Contribution to journalReview article

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