Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension

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Abstract

Objective. An index of large artery stiffness (SIDVP) simply derived from the digital volume pulse (DVP) was developed recently. However, the role of the SIDVP in untreated hypertensive patients was not well elucidated. Methods. We enrolled 124 untreated hypertensive patients (mean age 55.4 ± 13.1 years, 57 men). The DVP was measured in right index finger by a photoplethysmography. The SIDVP was formulated as body height divided by transition time from early systolic peak to the inflection point of reflection wave. Two functional indices of aortic compliance, stiffness index (SI) and distensibility (DI), were also used for measurement of aortic stiffness. Results. The SIDVP was significantly correlated with blood urea nitrogen (BUN), and left ventricular mass index (LVMI). Patients with vascular diseases had higher level of SIDVP (10.12±2.97 vs 8.45±1.78, p<0.001), SI (13.76±7.63 vs 10.87±8.88, p=0.116), BUN (28.4±24.7 vs 14.5±4.6, P<0.001) and lower level of DI (1.34±0.88 vs 1.93±1.12, p=0.010) than those without vascular diseases. By multivariate analysis, only the SIDVP was significantly associated with vascular diseases (OR 1.39, 95% CI 1.06-1.82, p=0.016). Conclusions. SIDVP, SI and DI were significantly correlated with target organ damage in untreated hypertension. However, only the SIDVP was independently associated with presence of vascular diseases. SIDVP simply derived from the DVP can be used as a marker for risk stratification in untreated hypertensive patients.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalBlood Pressure
Volume14
Issue number4
DOIs
Publication statusPublished - 2005 Oct 10

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Vascular Diseases
Hypertension
Vascular Stiffness
Blood Urea Nitrogen
Photoplethysmography
Body Height
Fingers
Compliance
Multivariate Analysis
Arteries

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

@article{b7018cbfc8994ffabfed84233a0a607d,
title = "Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension",
abstract = "Objective. An index of large artery stiffness (SIDVP) simply derived from the digital volume pulse (DVP) was developed recently. However, the role of the SIDVP in untreated hypertensive patients was not well elucidated. Methods. We enrolled 124 untreated hypertensive patients (mean age 55.4 ± 13.1 years, 57 men). The DVP was measured in right index finger by a photoplethysmography. The SIDVP was formulated as body height divided by transition time from early systolic peak to the inflection point of reflection wave. Two functional indices of aortic compliance, stiffness index (SI) and distensibility (DI), were also used for measurement of aortic stiffness. Results. The SIDVP was significantly correlated with blood urea nitrogen (BUN), and left ventricular mass index (LVMI). Patients with vascular diseases had higher level of SIDVP (10.12±2.97 vs 8.45±1.78, p<0.001), SI (13.76±7.63 vs 10.87±8.88, p=0.116), BUN (28.4±24.7 vs 14.5±4.6, P<0.001) and lower level of DI (1.34±0.88 vs 1.93±1.12, p=0.010) than those without vascular diseases. By multivariate analysis, only the SIDVP was significantly associated with vascular diseases (OR 1.39, 95{\%} CI 1.06-1.82, p=0.016). Conclusions. SIDVP, SI and DI were significantly correlated with target organ damage in untreated hypertension. However, only the SIDVP was independently associated with presence of vascular diseases. SIDVP simply derived from the DVP can be used as a marker for risk stratification in untreated hypertensive patients.",
author = "Zi-Yi Chen and Wei-Chuan Tsai and Chih-Chan Lin and Yao-Yi Huang and Chin-Hsin Hsu and Ping-Yen Liu and Chen, {Jyh Hong}",
year = "2005",
month = "10",
day = "10",
doi = "10.1080/08037050510034301",
language = "English",
volume = "14",
pages = "233--237",
journal = "Blood Pressure",
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T1 - Stiffness index derived from digital volume pulse as a marker of target organ damage in untreated hypertension

AU - Chen, Zi-Yi

AU - Tsai, Wei-Chuan

AU - Lin, Chih-Chan

AU - Huang, Yao-Yi

AU - Hsu, Chin-Hsin

AU - Liu, Ping-Yen

AU - Chen, Jyh Hong

PY - 2005/10/10

Y1 - 2005/10/10

N2 - Objective. An index of large artery stiffness (SIDVP) simply derived from the digital volume pulse (DVP) was developed recently. However, the role of the SIDVP in untreated hypertensive patients was not well elucidated. Methods. We enrolled 124 untreated hypertensive patients (mean age 55.4 ± 13.1 years, 57 men). The DVP was measured in right index finger by a photoplethysmography. The SIDVP was formulated as body height divided by transition time from early systolic peak to the inflection point of reflection wave. Two functional indices of aortic compliance, stiffness index (SI) and distensibility (DI), were also used for measurement of aortic stiffness. Results. The SIDVP was significantly correlated with blood urea nitrogen (BUN), and left ventricular mass index (LVMI). Patients with vascular diseases had higher level of SIDVP (10.12±2.97 vs 8.45±1.78, p<0.001), SI (13.76±7.63 vs 10.87±8.88, p=0.116), BUN (28.4±24.7 vs 14.5±4.6, P<0.001) and lower level of DI (1.34±0.88 vs 1.93±1.12, p=0.010) than those without vascular diseases. By multivariate analysis, only the SIDVP was significantly associated with vascular diseases (OR 1.39, 95% CI 1.06-1.82, p=0.016). Conclusions. SIDVP, SI and DI were significantly correlated with target organ damage in untreated hypertension. However, only the SIDVP was independently associated with presence of vascular diseases. SIDVP simply derived from the DVP can be used as a marker for risk stratification in untreated hypertensive patients.

AB - Objective. An index of large artery stiffness (SIDVP) simply derived from the digital volume pulse (DVP) was developed recently. However, the role of the SIDVP in untreated hypertensive patients was not well elucidated. Methods. We enrolled 124 untreated hypertensive patients (mean age 55.4 ± 13.1 years, 57 men). The DVP was measured in right index finger by a photoplethysmography. The SIDVP was formulated as body height divided by transition time from early systolic peak to the inflection point of reflection wave. Two functional indices of aortic compliance, stiffness index (SI) and distensibility (DI), were also used for measurement of aortic stiffness. Results. The SIDVP was significantly correlated with blood urea nitrogen (BUN), and left ventricular mass index (LVMI). Patients with vascular diseases had higher level of SIDVP (10.12±2.97 vs 8.45±1.78, p<0.001), SI (13.76±7.63 vs 10.87±8.88, p=0.116), BUN (28.4±24.7 vs 14.5±4.6, P<0.001) and lower level of DI (1.34±0.88 vs 1.93±1.12, p=0.010) than those without vascular diseases. By multivariate analysis, only the SIDVP was significantly associated with vascular diseases (OR 1.39, 95% CI 1.06-1.82, p=0.016). Conclusions. SIDVP, SI and DI were significantly correlated with target organ damage in untreated hypertension. However, only the SIDVP was independently associated with presence of vascular diseases. SIDVP simply derived from the DVP can be used as a marker for risk stratification in untreated hypertensive patients.

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JF - Blood Pressure

SN - 0803-7051

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