Stress Response in Cannabis Users and Psychosis

M. Bioque, Huai-Hsuan Tseng, R. Mizrahi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Stress exposure modifies the onset and evolution of several neuropsychiatric disorders. The dysregulation of the stress response, including dopamine release, is a potential etiological factor in the development and relapse of dopamine-related human disorders, including addictions and psychotic disorders. Exogenous cannabinoids alter the dopaminergic balance, and its effects could be potentiated in individuals experiencing adverse environmental stress. Chronic cannabis users present altered dopaminergic responses, suggesting blunted dopamine response to pharmacological and stress challenges.The endocannabinoid system, proposed as a main homeostatic system implicated in the regulation of the complex neuroimmune interactions in diverse neuropathological scenarios, may play a role as a possible link between stress, continuous cannabis use, and psychosis. Several studies have related endocannabinoid system alterations with psychotic disorders, and frequent cannabis exposure, especially in adolescence, may alter the endocannabinoid function in patients with schizophrenia, or in those at risk for the disease.

Original languageEnglish
Title of host publicationHandbook of Cannabis and Related Pathologies
Subtitle of host publicationBiology, Pharmacology, Diagnosis, and Treatment
PublisherElsevier Inc.
Pages278-287
Number of pages10
ISBN (Electronic)9780128008270
ISBN (Print)9780128007563
DOIs
Publication statusPublished - 2017 Jan 24

Fingerprint

Endocannabinoids
Cannabis
Psychotic Disorders
Dopamine
Cannabinoids
Schizophrenia
Pharmacology
Recurrence

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Bioque, M., Tseng, H-H., & Mizrahi, R. (2017). Stress Response in Cannabis Users and Psychosis. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment (pp. 278-287). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800756-3.00033-8
Bioque, M. ; Tseng, Huai-Hsuan ; Mizrahi, R. / Stress Response in Cannabis Users and Psychosis. Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., 2017. pp. 278-287
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Bioque, M, Tseng, H-H & Mizrahi, R 2017, Stress Response in Cannabis Users and Psychosis. in Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., pp. 278-287. https://doi.org/10.1016/B978-0-12-800756-3.00033-8

Stress Response in Cannabis Users and Psychosis. / Bioque, M.; Tseng, Huai-Hsuan; Mizrahi, R.

Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc., 2017. p. 278-287.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Bioque M, Tseng H-H, Mizrahi R. Stress Response in Cannabis Users and Psychosis. In Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment. Elsevier Inc. 2017. p. 278-287 https://doi.org/10.1016/B978-0-12-800756-3.00033-8