TY - JOUR
T1 - Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration
AU - Choi, Yeon Sik
AU - Hsueh, Yuan Yu
AU - Koo, Jahyun
AU - Yang, Quansan
AU - Avila, Raudel
AU - Hu, Buwei
AU - Xie, Zhaoqian
AU - Lee, Geumbee
AU - Ning, Zheng
AU - Liu, Claire
AU - Xu, Yameng
AU - Lee, Young Joong
AU - Zhao, Weikang
AU - Fang, Jun
AU - Deng, Yujun
AU - Lee, Seung Min
AU - Vázquez-Guardado, Abraham
AU - Stepien, Iwona
AU - Yan, Ying
AU - Song, Joseph W.
AU - Haney, Chad
AU - Oh, Yong Suk
AU - Liu, Wentai
AU - Yun, Hong Joon
AU - Banks, Anthony
AU - MacEwan, Matthew R.
AU - Ameer, Guillermo A.
AU - Ray, Wilson Z.
AU - Huang, Yonggang
AU - Xie, Tao
AU - Franz, Colin K.
AU - Li, Song
AU - Rogers, John A.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery.
AB - Bioresorbable electronic stimulators are of rapidly growing interest as unusual therapeutic platforms, i.e., bioelectronic medicines, for treating disease states, accelerating wound healing processes and eliminating infections. Here, we present advanced materials that support operation in these systems over clinically relevant timeframes, ultimately bioresorbing harmlessly to benign products without residues, to eliminate the need for surgical extraction. Our findings overcome key challenges of bioresorbable electronic devices by realizing lifetimes that match clinical needs. The devices exploit a bioresorbable dynamic covalent polymer that facilitates tight bonding to itself and other surfaces, as a soft, elastic substrate and encapsulation coating for wireless electronic components. We describe the underlying features and chemical design considerations for this polymer, and the biocompatibility of its constituent materials. In devices with optimized, wireless designs, these polymers enable stable, long-lived operation as distal stimulators in a rat model of peripheral nerve injuries, thereby demonstrating the potential of programmable long-term electrical stimulation for maintaining muscle receptivity and enhancing functional recovery.
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U2 - 10.1038/s41467-020-19660-6
DO - 10.1038/s41467-020-19660-6
M3 - Article
C2 - 33239608
AN - SCOPUS:85096525977
SN - 2041-1723
VL - 11
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 5990
ER -