Stretching DNA with electric fields beneath submicron interfacial constriction created by a closely fitting microdroplet in a microchannel

Shu Fu Hsieh, Chia Pu Chang, Yi Je Juang, Hsien Hung Wei

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this article, we report an alternative strategy for stretching single DNA molecules with electric fields. The approach invokes a closely fitting microdroplet in a microchannel, creating a natural converging geometry for stretching DNA within a submicron interfacial constriction. We demonstrate that DNA molecules can undergo prestretching within the constriction, pseudotethering entropic trap, and rapid extension within the thin film underneath the droplet. An elastic dumbbell model is derived to account for the observed stretch behavior, with predictions in good agreement with the experimental results.

Original languageEnglish
Article number084103
JournalApplied Physics Letters
Volume93
Issue number8
DOIs
Publication statusPublished - 2008 Sep 15

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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