Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1

Tsung Hua Lu; Shih Hsien Lin; Huai Hsuan Tseng; Yen Kuang Yang; Nan Tsing Chiu; Po See Chen

doi:10.9758/CPN.2022.20.4.768

Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [^99mTc] TRODAT-1

Tsung Hua Lu, Shih Hsien Lin, Huai Hsuan Tseng, Yen Kuang Yang, Nan Tsing Chiu, Po See Chen

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [^99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.

Original language	English
Pages (from-to)	768-772
Number of pages	5
Journal	Clinical Psychopharmacology and Neuroscience
Volume	20
Issue number	4
DOIs	https://doi.org/10.9758/CPN.2022.20.4.768
Publication status	Published - 2022

All Science Journal Classification (ASJC) codes

Psychiatry and Mental health
Behavioral Neuroscience
Pharmacology (medical)

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10.9758/CPN.2022.20.4.768

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Lu, T. H., Lin, S. H., Tseng, H. H., Yang, Y. K., Chiu, N. T., & Chen, P. S. (2022). Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [^99mTc] TRODAT-1. Clinical Psychopharmacology and Neuroscience, 20(4), 768-772. https://doi.org/10.9758/CPN.2022.20.4.768

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title = "Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1",

abstract = "Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.",

author = "Lu, {Tsung Hua} and Lin, {Shih Hsien} and Tseng, {Huai Hsuan} and Yang, {Yen Kuang} and Chiu, {Nan Tsing} and Chen, {Po See}",

note = "Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 104-2321-B-006-031, MOST 106-2410-H-468-012-MY2, MOST 107-2314-B-006-082, MOST 107-2628-B-006-005-, MOST 108-2320-B-006-004-, MOST 108-2410-H-468-009, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital (NCKUH-10704010 and NCKUH-10902014). Publisher Copyright: Copyright {\textcopyright} 2022, Korean College of Neuropsychopharmacology.",

year = "2022",

doi = "10.9758/CPN.2022.20.4.768",

language = "English",

volume = "20",

pages = "768--772",

journal = "Clinical Psychopharmacology and Neuroscience",

issn = "1738-1088",

publisher = "Korean College of Neuropsychopharmacology",

number = "4",

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Lu, TH, Lin, SH, Tseng, HH , Yang, YK , Chiu, NT & Chen, PS 2022, 'Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [^99mTc] TRODAT-1', Clinical Psychopharmacology and Neuroscience, vol. 20, no. 4, pp. 768-772. https://doi.org/10.9758/CPN.2022.20.4.768

Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [^99mTc] TRODAT-1. / Lu, Tsung Hua; Lin, Shih Hsien; Tseng, Huai Hsuan et al.
In: Clinical Psychopharmacology and Neuroscience, Vol. 20, No. 4, 2022, p. 768-772.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder

T2 - A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1

AU - Lu, Tsung Hua

AU - Lin, Shih Hsien

AU - Tseng, Huai Hsuan

AU - Yang, Yen Kuang

AU - Chiu, Nan Tsing

AU - Chen, Po See

N1 - Funding Information: This work was supported by the Ministry of Science and Technology, Taiwan (MOST 104-2321-B-006-031, MOST 106-2410-H-468-012-MY2, MOST 107-2314-B-006-082, MOST 107-2628-B-006-005-, MOST 108-2320-B-006-004-, MOST 108-2410-H-468-009, and MOST 109-2628-B-006-004-) and National Cheng Kung University Hospital (NCKUH-10704010 and NCKUH-10902014). Publisher Copyright: Copyright © 2022, Korean College of Neuropsychopharmacology.

PY - 2022

Y1 - 2022

N2 - Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.

AB - Objective: Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear. Methods: Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1. Results: The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD. Conclusion: The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.

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DO - 10.9758/CPN.2022.20.4.768

M3 - Article

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SN - 1738-1088

VL - 20

SP - 768

EP - 772

JO - Clinical Psychopharmacology and Neuroscience

JF - Clinical Psychopharmacology and Neuroscience

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Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [^99mTc] TRODAT-1

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