Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein

Senyan Zhang, Panpan Zhou, Pengfei Wang, Yangyang Li, Liwei Jiang, Wenxu Jia, Han Wang, Angela Fan, Dongli Wang, Xuanling Shi, Xianyang Fang, Michal Hammel, Shu-Ying Wang, Xinquan Wang, Linqi Zhang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Zhang et al. report the structural and functional analysis of the potent MERS-CoV neutralizing antibody MERS-4. MERS-4 recognizes a unique epitope and indirectly disrupts interaction between the receptor binding domain and the receptor DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.

Original languageEnglish
Pages (from-to)441-452
Number of pages12
JournalCell Reports
Volume24
Issue number2
DOIs
Publication statusPublished - 2018 Jul 10

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Functional analysis
Neutralizing Antibodies
Structural analysis
Epitopes
Glycoproteins
Antibodies
Infection
Middle East Respiratory Syndrome Coronavirus

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zhang, Senyan ; Zhou, Panpan ; Wang, Pengfei ; Li, Yangyang ; Jiang, Liwei ; Jia, Wenxu ; Wang, Han ; Fan, Angela ; Wang, Dongli ; Shi, Xuanling ; Fang, Xianyang ; Hammel, Michal ; Wang, Shu-Ying ; Wang, Xinquan ; Zhang, Linqi. / Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. In: Cell Reports. 2018 ; Vol. 24, No. 2. pp. 441-452.
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author = "Senyan Zhang and Panpan Zhou and Pengfei Wang and Yangyang Li and Liwei Jiang and Wenxu Jia and Han Wang and Angela Fan and Dongli Wang and Xuanling Shi and Xianyang Fang and Michal Hammel and Shu-Ying Wang and Xinquan Wang and Linqi Zhang",
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Zhang, S, Zhou, P, Wang, P, Li, Y, Jiang, L, Jia, W, Wang, H, Fan, A, Wang, D, Shi, X, Fang, X, Hammel, M, Wang, S-Y, Wang, X & Zhang, L 2018, 'Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein', Cell Reports, vol. 24, no. 2, pp. 441-452. https://doi.org/10.1016/j.celrep.2018.06.041

Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. / Zhang, Senyan; Zhou, Panpan; Wang, Pengfei; Li, Yangyang; Jiang, Liwei; Jia, Wenxu; Wang, Han; Fan, Angela; Wang, Dongli; Shi, Xuanling; Fang, Xianyang; Hammel, Michal; Wang, Shu-Ying; Wang, Xinquan; Zhang, Linqi.

In: Cell Reports, Vol. 24, No. 2, 10.07.2018, p. 441-452.

Research output: Contribution to journalArticle

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AU - Jiang, Liwei

AU - Jia, Wenxu

AU - Wang, Han

AU - Fan, Angela

AU - Wang, Dongli

AU - Shi, Xuanling

AU - Fang, Xianyang

AU - Hammel, Michal

AU - Wang, Shu-Ying

AU - Wang, Xinquan

AU - Zhang, Linqi

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