@article{e39d0237fc274026a85f1805a289bf56,
title = "Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein",
abstract = "Zhang et al. report the structural and functional analysis of the potent MERS-CoV neutralizing antibody MERS-4. MERS-4 recognizes a unique epitope and indirectly disrupts interaction between the receptor binding domain and the receptor DPP4. This mechanism provides a valuable addition for the combined use of antibodies against MERS-CoV infection.",
author = "Senyan Zhang and Panpan Zhou and Pengfei Wang and Yangyang Li and Liwei Jiang and Wenxu Jia and Han Wang and Angela Fan and Dongli Wang and Xuanling Shi and Xianyang Fang and Michal Hammel and Shuying Wang and Xinquan Wang and Linqi Zhang",
note = "Funding Information: We thank Dr. Jianhua He and staff scientists at the SSRF BL17U beam line and Dr. Shilong Fan at the X-ray crystallography platform of the Tsinghua University Technology Center for assistance in diffraction data collection. We thank Prof. Tianlei Ying and Prof. Shibo Jiang (Fudan University) for providing the m336. We thank Prof. Wenjie Tan (Chinese Center for Disease Control and Prevention) for providing the 5F9. This work was supported by the National Key Plan for Scientific Research and Development of China (grants 2016YFD0500307 and 2016YFC1200902), the National Natural Science Foundation of China (grants 31470751, U1405228, 81530065, and 81471929), and the Grand Challenges China (grant 81661128042). Funding Information: We thank Dr. Jianhua He and staff scientists at the SSRF BL17U beam line and Dr. Shilong Fan at the X-ray crystallography platform of the Tsinghua University Technology Center for assistance in diffraction data collection. We thank Prof. Tianlei Ying and Prof. Shibo Jiang (Fudan University) for providing the m336. We thank Prof. Wenjie Tan (Chinese Center for Disease Control and Prevention) for providing the 5F9. This work was supported by the National Key Plan for Scientific Research and Development of China (grants 2016YFD0500307 and 2016YFC1200902 ), the National Natural Science Foundation of China (grants 31470751 , U1405228 , 81530065 , and 81471929 ), and the Grand Challenges China (grant 81661128042 ). ",
year = "2018",
month = jul,
day = "10",
doi = "10.1016/j.celrep.2018.06.041",
language = "English",
volume = "24",
pages = "441--452",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}