Structural Elucidation of Murrafolines, Six Novel Binary Carbazole Alkaloids Isolated from Murraya euchrestifolia

Hiroshi Furukawa, Chihiro Ito, Tian Shung Wu, Andrew T. McPhail

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16 Citations (Scopus)

Abstract

In previous studies on the chemical constituents of Murraya euchrestifolia hayata(Rutaceae) collected in Taiwan, we preliminarily reported the first isolation and structure of a binary carbazole alkaloid, murrafoline-A (1). Since then, the isolation and spectroscopic structural elucidation of three new binary carbazoles, murrafoline-B (2), -C (5), and -D (3), have been reported. This paper describes in detail the structural elucidation of these novel binary carbazole alkaloids and also introduces two additional ones, murrafoline-G (4) and -H (6). Treatment of a mixture of girinimbine (7) and murrayafoline-A (8), which are monomeric carbazoles and structural components of murrafolines, with Nafion 117, an acidic perfluorinated ion-exchange resin, was found to produce murrafoline-D (3), -G (4), and -H (6).

Original languageEnglish
Pages (from-to)1249-1254
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume41
Issue number7
DOIs
Publication statusPublished - 1993 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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