Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from clausena excavata

Tian Shung Wu; Shiow Chyn Huang; Pei0Lin Wu; Kuo Hsiung Lee

doi:10.1016/S0960-894X(01)80397-8

Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from clausena excavata

Tian Shung Wu, Shiow Chyn Huang, Pei0Lin Wu, Kuo Hsiung Lee

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A new carbazolequinone alkaloid, clausenaquinone-A, has been isolated from the stem bark of Clausena excavata. The structure has been established from spectral data and total synthesis. Clausenaquinone-A shows potent inhibitory activity of the rabbit platelet aggregation as well as cytotoxicity in HCT-8, RPMI-7951, and TE671 tumor cells.

Original language	English
Pages (from-to)	2395-2398
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	20
DOIs	https://doi.org/10.1016/S0960-894X(01)80397-8
Publication status	Published - 1994

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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abstract = "A new carbazolequinone alkaloid, clausenaquinone-A, has been isolated from the stem bark of Clausena excavata. The structure has been established from spectral data and total synthesis. Clausenaquinone-A shows potent inhibitory activity of the rabbit platelet aggregation as well as cytotoxicity in HCT-8, RPMI-7951, and TE671 tumor cells.",

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AU - Lee, Kuo Hsiung

PY - 1994

Y1 - 1994

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AB - A new carbazolequinone alkaloid, clausenaquinone-A, has been isolated from the stem bark of Clausena excavata. The structure has been established from spectral data and total synthesis. Clausenaquinone-A shows potent inhibitory activity of the rabbit platelet aggregation as well as cytotoxicity in HCT-8, RPMI-7951, and TE671 tumor cells.

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Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from clausena excavata

Abstract

All Science Journal Classification (ASJC) codes

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