Structure and synthesis of clausenaquinone-a. A novel carbazolequinone alkaloid and bioactive principle from clausena excavata

Tian Shung Wu, Shiow Chyn Huang, Pei0Lin Wu, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A new carbazolequinone alkaloid, clausenaquinone-A, has been isolated from the stem bark of Clausena excavata. The structure has been established from spectral data and total synthesis. Clausenaquinone-A shows potent inhibitory activity of the rabbit platelet aggregation as well as cytotoxicity in HCT-8, RPMI-7951, and TE671 tumor cells.

Original languageEnglish
Pages (from-to)2395-2398
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number20
DOIs
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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