Structure and synthesis of murrapanine, a novel skeletal indole-naphthoquinone alkaloid and cytotoxic principal from Murraya paniculata var. omphalocarpa

Tian Shung Wu, Meei Jen Liou, Chwan Jen Lee, Ting Ting Jong, Andrew T. McPhail, Donald R. McPhail, Kuo Hsiung Lee

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

A novel skeletal cytotoxic indole-naphthoquinone alkaloid, murrapanine, has been isolated from the root bark of Murraya paniculata var. omphalocarpa and its structure has been established from spectral data and single-crystal X-ray analysis; the synthesis of murrapanine from indole-3-aldehyde is also described.

Original languageEnglish
Pages (from-to)6649-6652
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number48
DOIs
Publication statusPublished - 1989

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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