Structure, properties and animal study of a calcium phosphate/calcium sulfate composite cement

Wei Luen Chen, Chang Keng Chen, Jing Wei Lee, Yu Ling Lee, Chien Ping Ju, Jiin Huey Chern Lin

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


In-vitro and in-vivo studies have been conducted on an in-house-developed tetracalcium phosphate (TTCP)/dicalcium phosphate anhydrous (DCPA)/calcium sulfate hemihydrate (CSH)-derived composite cement. Unlike most commercial calcium-based cement pastes, the investigated cement paste can be directly injected into water and harden without dispersion. The viability value of cells incubated with a conditioned medium of cement extraction is > 90% that of Al2O3 control and > 80% that of blank medium. Histological examination reveals excellent bonding between host bone and cement without interposition of fibrous tissues. At 12 weeks-post implantation, significant remodeling activities are found and a new bone network is developed within the femoral defect. The 26-week samples show that the newly formed bone becomes more mature, while the interface between residual cement and the new bone appears less identifiable. Image analysis indicates that the resorption rate of the present cement is much higher than that of TTCP or TTCP/DCPA-derived cement under similar implantation conditions.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalMaterials Science and Engineering C
Issue number1
Publication statusPublished - 2014 Apr 1

All Science Journal Classification (ASJC) codes

  • General Medicine


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