Study of encapsulated microbubble cluster based on association schemes perspective

S. Behnia, M. Yahyavi, R. Habibpourbisafar, F. Mottaghi

Research output: Contribution to journalArticle

Abstract

Ultrasound contrast agents have been recently utilized in therapeutical implementations for targeted delivery of pharmaceutical substances. Radial pulsations of a cluster of encapsulated microbubbles under the action of an ultrasound field are complex and highly nonlinear, particularly for drug and gene delivery applications with high acoustic pressure amplitudes. In this paper, based on Qin-Ferrara's model (Qin and Ferrara, 2010), the complete synchronization and cluster formation in targeted microbubbles network are studied. Also, association schemes as a novel approach are suggested for finding a relationship between coupled microbubbles elements which are immersed in blood or surrounding soft tissue. A significant advantage of this method is that the stability of the synchronized state (or symmetric eigenmode of mutual bubble oscillation) with respect to another state (another eigenmode) can now predict. More interestingly, we find a significant relationship between an isolated and multiple microbubbles. The results show that the problem of studying the dynamics of encapsulated microbubble cluster at synchronization state is dependent on the dynamical characteristics of isolated cases, shell thickness, density. Also, the distance between microbubbles has an important role in their synchronous modes.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalUltrasonics Sonochemistry
Volume52
DOIs
Publication statusPublished - 2019 Apr

Fingerprint

Microbubbles
Synchronization
drug
Ultrasonics
synchronism
delivery
Pharmaceutical Preparations
Drug products
Contrast Media
bubble
Blood
acoustics
Genes
blood
Acoustics
oscillation
shell
Tissue
genes
gene

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Environmental Chemistry
  • Radiology Nuclear Medicine and imaging
  • Acoustics and Ultrasonics
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Behnia, S. ; Yahyavi, M. ; Habibpourbisafar, R. ; Mottaghi, F. / Study of encapsulated microbubble cluster based on association schemes perspective. In: Ultrasonics Sonochemistry. 2019 ; Vol. 52. pp. 131-141.
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Study of encapsulated microbubble cluster based on association schemes perspective. / Behnia, S.; Yahyavi, M.; Habibpourbisafar, R.; Mottaghi, F.

In: Ultrasonics Sonochemistry, Vol. 52, 04.2019, p. 131-141.

Research output: Contribution to journalArticle

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