Study of polyvinyl alcohol nanofibrous membrane by electrospinning as a magnetic nanoparticle delivery approach

Tzong Rong Ger, Hao Ting Huang, Chen Yu Huang, Keng Shiang Hu, Jun Yang Lai, Jiann Yeu Chen, Mei Feng Lai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Electrospinning technique was used to fabricate polyvinyl alcohol (PVA)-based magnetic biodegradable nanofibers. PVA solution was mixed with ferrofluid or magnetic nanoparticles (MNPs) powder and formed two individual nanofibrous membranes (PVA/ferrofluid and PVA/MNPs powder) by electrospinning. The surface morphology of the nanofibrous membrane was characterized by scanning electron microscopy and the magnetic properties were measured by vibrating sample magnetometer. Macrophages (RAW 264.7) were co-cultured with the nanofibrous membranes for 12, 24, and 48 h and exhibited good cell viability (>95%). Results showed that the PVA fibers would be degraded and the embedded Fe3O4 nanoparticles would be released and delivered to cells.

Original languageEnglish
Article number17B908
JournalJournal of Applied Physics
Volume115
Issue number17
DOIs
Publication statusPublished - 2014 May 7

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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