Abstract
The cellular force is one of the most important parameters of cellular physiological behavior and mechanical interactions between the cell and its environment which could regulate the cell migration, contractility and gene expression. In order to evidence the characteristics of the physiology and cellular mechanics of the epithelial cells, therefore, we use the micro-pillars arrays (MPAs) to measure the traction force of the Madin-Darby canine kidney (MDCK) cells. When MDCK cells adhere on the different geometry of MPAs, the cell will pull MPAs and cause the pillars displacement due to the traction force. Furthermore, the cellular image and the displacement of the pillars could be analyzed by optic microscope system, and could be evaluated the mechanical interactions between the cells and MPAs. Therefore, this method might help us understand the cellular mechanics and physiological phenomenon between the cells and underlying substrates.
| Original language | English |
|---|---|
| Title of host publication | Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 |
| Pages | 1125-1128 |
| Number of pages | 4 |
| DOIs | |
| Publication status | Published - 2007 Aug 28 |
| Event | 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand Duration: 2007 Jan 16 → 2007 Jan 19 |
Publication series
| Name | Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 |
|---|
Other
| Other | 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 |
|---|---|
| Country | Thailand |
| City | Bangkok |
| Period | 07-01-16 → 07-01-19 |
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All Science Journal Classification (ASJC) codes
- Computer Networks and Communications
- Computer Science Applications
- Electrical and Electronic Engineering
Cite this
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Study on the cell mechanics of MDCK cells by elastic micro-pillars arrays. / Wang, Chien Wen; Chen, Wei Ren; Wu, Ching Chou; Chang, Hsien-Chang.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1125-1128 4160518 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
TY - GEN
T1 - Study on the cell mechanics of MDCK cells by elastic micro-pillars arrays
AU - Wang, Chien Wen
AU - Chen, Wei Ren
AU - Wu, Ching Chou
AU - Chang, Hsien-Chang
PY - 2007/8/28
Y1 - 2007/8/28
N2 - The cellular force is one of the most important parameters of cellular physiological behavior and mechanical interactions between the cell and its environment which could regulate the cell migration, contractility and gene expression. In order to evidence the characteristics of the physiology and cellular mechanics of the epithelial cells, therefore, we use the micro-pillars arrays (MPAs) to measure the traction force of the Madin-Darby canine kidney (MDCK) cells. When MDCK cells adhere on the different geometry of MPAs, the cell will pull MPAs and cause the pillars displacement due to the traction force. Furthermore, the cellular image and the displacement of the pillars could be analyzed by optic microscope system, and could be evaluated the mechanical interactions between the cells and MPAs. Therefore, this method might help us understand the cellular mechanics and physiological phenomenon between the cells and underlying substrates.
AB - The cellular force is one of the most important parameters of cellular physiological behavior and mechanical interactions between the cell and its environment which could regulate the cell migration, contractility and gene expression. In order to evidence the characteristics of the physiology and cellular mechanics of the epithelial cells, therefore, we use the micro-pillars arrays (MPAs) to measure the traction force of the Madin-Darby canine kidney (MDCK) cells. When MDCK cells adhere on the different geometry of MPAs, the cell will pull MPAs and cause the pillars displacement due to the traction force. Furthermore, the cellular image and the displacement of the pillars could be analyzed by optic microscope system, and could be evaluated the mechanical interactions between the cells and MPAs. Therefore, this method might help us understand the cellular mechanics and physiological phenomenon between the cells and underlying substrates.
UR - http://www.scopus.com/inward/record.url?scp=34548129917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548129917&partnerID=8YFLogxK
U2 - 10.1109/NEMS.2007.352215
DO - 10.1109/NEMS.2007.352215
M3 - Conference contribution
SN - 1424406102
SN - 9781424406104
T3 - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
SP - 1125
EP - 1128
BT - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
ER -