Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Wei Ren Chen, Pei Yu Huang, Chien Wen Wang, Yi Dong Lin, Chi Chang Lin, Hsien-Chang Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

Original languageEnglish
Title of host publicationProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages1129-1132
Number of pages4
DOIs
Publication statusPublished - 2007 Aug 28
Event2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand
Duration: 2007 Jan 162007 Jan 19

Publication series

NameProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
CountryThailand
CityBangkok
Period07-01-1607-01-19

All Science Journal Classification (ASJC) codes

  • Computer Networks and Communications
  • Computer Science Applications
  • Electrical and Electronic Engineering

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