Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Wei Ren Chen; Pei Yu Huang; Chien Wen Wang; Yi Dong Lin; Chi Chang Lin; Hsien Chang Chang

doi:10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Wei Ren Chen
, Pei Yu Huang
, Chien Wen Wang
, Yi Dong Lin
, Chi Chang Lin
, Hsien Chang Chang

Department of Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

Original language	English
Title of host publication	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Pages	1129-1132
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2007.352216
Publication status	Published - 2007
Event	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, Thailand Duration: 2007 Jan 16 → 2007 Jan 19

Publication series

Name	Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

Other

Other	2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
Country/Territory	Thailand
City	Bangkok
Period	07-01-16 → 07-01-19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Computer Networks and Communications
Computer Science Applications
Electrical and Electronic Engineering

Access to Document

10.1109/NEMS.2007.352216

Cite this

Chen, W. R., Huang, P. Y., Wang, C. W., Lin, Y. D., Lin, C. C., & Chang, H. C. (2007). Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 (pp. 1129-1132). Article 4160519 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). https://doi.org/10.1109/NEMS.2007.352216

Chen, Wei Ren ; Huang, Pei Yu ; Wang, Chien Wen et al. / Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. pp. 1129-1132 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

@inproceedings{daa9168b8a664d76bc7f316a773f7d75,

title = "Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays",

abstract = "According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.",

author = "Chen, \{Wei Ren\} and Huang, \{Pei Yu\} and Wang, \{Chien Wen\} and Lin, \{Yi Dong\} and Lin, \{Chi Chang\} and Chang, \{Hsien Chang\}",

year = "2007",

doi = "10.1109/NEMS.2007.352216",

language = "English",

isbn = "1424406102",

series = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

pages = "1129--1132",

booktitle = "Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007",

note = "2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 ; Conference date: 16-01-2007 Through 19-01-2007",

}

Chen, WR, Huang, PY, Wang, CW, Lin, YD, Lin, CC & Chang, HC 2007, Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. in Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007., 4160519, Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, pp. 1129-1132, 2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007, Bangkok, Thailand, 07-01-16. https://doi.org/10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. / Chen, Wei Ren; Huang, Pei Yu; Wang, Chien Wen et al.
Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1129-1132 4160519 (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

AU - Chen, Wei Ren

AU - Huang, Pei Yu

AU - Wang, Chien Wen

AU - Lin, Yi Dong

AU - Lin, Chi Chang

AU - Chang, Hsien Chang

PY - 2007

Y1 - 2007

N2 - According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

AB - According to the concept of cell physiology, when the cells contact the extracellular matrix (ECM), the cell will adhere, spread and migrates. Despite the sophistication of experimental and computational approaches in cell and molecular biology, the mechanisms by which cells sense and respond to mechanical stimuli are poorly understood. In order to evaluate the characteristics of the cellular physiology, we use Atomic force microscopy (AFM) and Micro-pillars arrays (MPAs) to measure the cell mechanics of the oral epithelia carcinoma cells (OEC-M1). After AFM measurement, the stiffness of the OEC-M1-wt was 41-95 kPa, meanwhile the OEC-M1-g6 was 21-46 kPa. In deed, 0.88-4.75 nN of the traction force was generated in OEC-M1-g6 cells, which the actin filament assemble around the cytoplasm might caused by the gelsolin, after forward, both the adherent and moving ability of the cells were increased.

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AN - SCOPUS:34548126833

SN - 1424406102

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T3 - Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

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Y2 - 16 January 2007 through 19 January 2007

ER -

Chen WR, Huang PY, Wang CW, Lin YD, Lin CC, Chang HC. Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays. In Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007. 2007. p. 1129-1132. 4160519. (Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007). doi: 10.1109/NEMS.2007.352216

Study on the gelsolin effects in oral epithelia carcinoma (OEC) cells by atomic force microscopy and micro-pillars arrays

Abstract

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