Studying disorder-to-order transitions from structural analysis

Tien Hao Chang, Chih Yun Chiang, Fung Wei Lin, Chen Yu Fan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Many proteins and protein regions have been reported to be intrinsically disordered. Such disordered regions have been found to have conformational changes in various biological processes. Comprehensive studies on these disordered regions provide useful clues in understanding the mechanisms of a living cell. However, previous analyses only provided an overall number of disorder residues without definitely identifying the conformational changes. Besides, the variance of different binding types was averaged but not individually investigated. In this study, we have compiled a collection of structure pairs where the two members are identical except that one has an extra molecule than the other. This design, which enlarged the collection of analyzing targets with more various structures, is one of the most distinct features of this work to previous studies. By constructing the complete maps of every residue between two structures, this study performed more detailed and specific analyses than previous studies.

Original languageEnglish
Title of host publication2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011
Pages52-56
Number of pages5
DOIs
Publication statusPublished - 2011 Apr 14
Event1st IEEE International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011 - Orlando, FL, United States
Duration: 2011 Feb 32011 Feb 5

Publication series

Name2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011

Other

Other1st IEEE International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011
CountryUnited States
CityOrlando, FL
Period11-02-0311-02-05

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Health Informatics

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    Chang, T. H., Chiang, C. Y., Lin, F. W., & Fan, C. Y. (2011). Studying disorder-to-order transitions from structural analysis. In 2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011 (pp. 52-56). [5729940] (2011 IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences, ICCABS 2011). https://doi.org/10.1109/ICCABS.2011.5729940