Abstract
Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED50)), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED25, ED50 and ED75), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.
| Original language | English |
|---|---|
| Pages (from-to) | 565-569 |
| Number of pages | 5 |
| Journal | Pharmacological Reports |
| Volume | 70 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2018 Jun |
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All Science Journal Classification (ASJC) codes
- Pharmacology
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Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats. / Hung, Ching Hsia; Shieh, Ja Ping; Chiu, Chong Chi; Wang, Jhi Joung; Chen, Yu Wen.
In: Pharmacological Reports, Vol. 70, No. 3, 06.2018, p. 565-569.Research output: Contribution to journal › Article
TY - JOUR
T1 - Subcutaneous infiltration of doxylamine on cutaneous analgesia in rats
AU - Hung, Ching Hsia
AU - Shieh, Ja Ping
AU - Chiu, Chong Chi
AU - Wang, Jhi Joung
AU - Chen, Yu Wen
PY - 2018/6
Y1 - 2018/6
N2 - Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED50)), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED25, ED50 and ED75), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.
AB - Background: We aimed to evaluate the effect of doxylamine, a first generation antihistamine, as a local analgesic agent by comparing its effect to bupivacaine. Methods: After blocking the cutaneous trunci muscle reflex (CTMR) by subcutaneous injection of doxylamine, we assessed doxylamine's cutaneous analgesic effect in rats. The dose-related effect and duration of doxylamine on infiltrative cutaneous analgesia were compared with that of bupivacaine. Results: We demonstrated that doxylamine, as well as the local anesthetic bupivacaine produced the cutaneous analgesic effects in a dose-related fashion. At the equipotent dose (50% effective doses (ED50)), the relative potency was bupivacaine (0.41 (0.36–0.48) mmol)> doxylamine (7.39 (6.91–7.91) mmol) (p < 0.01). On an equipotent basis (ED25, ED50 and ED75), subcutaneous doxylamine resulted in greater duration of action (p < 0.01) than bupivacaine at producing cutaneous analgesia. Conclusions: The result of this experiment indicated that doxylamine has the local anesthetic property less potent than bupivacaine, but its nociceptive block duration is longer than that of bupivacaine at an equianalgesic dose.
UR - http://www.scopus.com/inward/record.url?scp=85045638610&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045638610&partnerID=8YFLogxK
U2 - 10.1016/j.pharep.2017.12.006
DO - 10.1016/j.pharep.2017.12.006
M3 - Article
C2 - 29679880
AN - SCOPUS:85045638610
VL - 70
SP - 565
EP - 569
JO - Pharmacological Reports
JF - Pharmacological Reports
SN - 1734-1140
IS - 3
ER -