Substance P release evoked by hypertonic saline on nasal mucosa

M. Y. Lin, Sheen-Yie Fang

Research output: Contribution to journalArticlepeer-review


Background: Non-specific stimuli such as histamine, cold air, and hypertonic saline will induce mucosal inflammation of the respiratory tract. Among these, hypertonic saline may also cause ophthalmic neurogenic inflammation, cough, and hypersecretion though its pathogenesis is still unclear. Hypertonic saline may induce the release of a sensory neuropeptide- substance P from the nociceptive nerves, causing subsequent neurogenic inflammation, such as hypersecretion, vascular hyperpermeability and submucosal edema. There has been no report involving sensory neuropeptide- substance P release induced by hypertonic saline in human nasal mucosa. Thus, we evaluated the substance P response in the nasal secretion after the stimulation of various concentrations of hypertonic saline. Materials and Methods: The right nasal cavity of 10 volunteers without any nasal disease was stimulated by various concentrations of hypertonic saline. Then the nasal secretion of both nasal cavities were individually collected and immediately stored at -70 °C. The concentrations of substance P of the secretion were measured using radioimmunoassay. Results: There was an increasing trend of substance P concentration in nasal secretion, correlating to the concentration of hypertonic saline in the stimulated nasal cavity. However, there was no significant change in the opposite site. Conclusion: The hypertonic saline may induce neurogenic inflammation of the respiratory mucosa through the substance P release from nociceptive fibers.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalJournal of Taiwan Otolaryngology - Head and Neck Surgery
Issue number1
Publication statusPublished - 1999 Jan 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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