Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Chao Hsun Chen, Shan Wen Chen, Wan Lin Shen, Tsai-Yun Chen, Chao Jung Tsao, Wen Tsung Huang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Anaplastic lymphoma kinase (ALK) expression exists in approximately 60% of anaplastic large cell lymphoma (ALCL) cases. Compared with the ALK-negative cases, ALK-positive cases are usually characterized by a good response to chemotherapy and a good prognosis. In the relapsed or refractory ALCL cases, high-dose chemotherapy followed by autologous stem cell transplantation has been widely used as a salvage therapy. However, 40% of patients who received transplants after more than 2 complete remissions eventually experienced disease progression, despite receiving autologous stem cell transplantation. Allogeneic stem cell transplantation has been proposed as a therapeutic option in refractory ALCL cases, but clinical reports of adult patients are rare. Herein, we report the case of an adult with refractory ALK-positive ALCL who was successfully treated with salvage high-dose chemotherapy followed by allogeneic stem cell transplantation.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalInternational Journal of Hematology
Volume85
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

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Anaplastic Large-Cell Lymphoma
Stem Cell Transplantation
Drug Therapy
Salvage Therapy
Disease Progression
Transplants
anaplastic lymphoma kinase

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Chen, Chao Hsun ; Chen, Shan Wen ; Shen, Wan Lin ; Chen, Tsai-Yun ; Tsao, Chao Jung ; Huang, Wen Tsung. / Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. In: International Journal of Hematology. 2007 ; Vol. 85, No. 2. pp. 105-107.
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abstract = "Anaplastic lymphoma kinase (ALK) expression exists in approximately 60{\%} of anaplastic large cell lymphoma (ALCL) cases. Compared with the ALK-negative cases, ALK-positive cases are usually characterized by a good response to chemotherapy and a good prognosis. In the relapsed or refractory ALCL cases, high-dose chemotherapy followed by autologous stem cell transplantation has been widely used as a salvage therapy. However, 40{\%} of patients who received transplants after more than 2 complete remissions eventually experienced disease progression, despite receiving autologous stem cell transplantation. Allogeneic stem cell transplantation has been proposed as a therapeutic option in refractory ALCL cases, but clinical reports of adult patients are rare. Herein, we report the case of an adult with refractory ALK-positive ALCL who was successfully treated with salvage high-dose chemotherapy followed by allogeneic stem cell transplantation.",
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Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. / Chen, Chao Hsun; Chen, Shan Wen; Shen, Wan Lin; Chen, Tsai-Yun; Tsao, Chao Jung; Huang, Wen Tsung.

In: International Journal of Hematology, Vol. 85, No. 2, 01.02.2007, p. 105-107.

Research output: Contribution to journalArticle

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AU - Chen, Shan Wen

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AU - Tsao, Chao Jung

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