Successful allogeneic stem cell transplantation for an adult with refractory anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Chao Hsun Chen, Shan Wen Chen, Wan Lin Shen, Tsai Yun Chen, Chao Jung Tsao, Wen Tsung Huang

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Anaplastic lymphoma kinase (ALK) expression exists in approximately 60% of anaplastic large cell lymphoma (ALCL) cases. Compared with the ALK-negative cases, ALK-positive cases are usually characterized by a good response to chemotherapy and a good prognosis. In the relapsed or refractory ALCL cases, high-dose chemotherapy followed by autologous stem cell transplantation has been widely used as a salvage therapy. However, 40% of patients who received transplants after more than 2 complete remissions eventually experienced disease progression, despite receiving autologous stem cell transplantation. Allogeneic stem cell transplantation has been proposed as a therapeutic option in refractory ALCL cases, but clinical reports of adult patients are rare. Herein, we report the case of an adult with refractory ALK-positive ALCL who was successfully treated with salvage high-dose chemotherapy followed by allogeneic stem cell transplantation.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalInternational Journal of Hematology
Volume85
Issue number2
DOIs
Publication statusPublished - 2007 Feb

All Science Journal Classification (ASJC) codes

  • Hematology

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