Sugar transporters for intercellular exchange and nutrition of pathogens

Li Qing Chen, Bi Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung, Xiao Qing Qu, Woei-Jiun Guo, Jung Gun Kim, William Underwood, Bhavna Chaudhuri, Diane Chermak, Ginny Antony, Frank F. White, Shauna C. Somerville, Mary Beth Mudgett, Wolf B. Frommer

Research output: Contribution to journalArticle

551 Citations (Scopus)

Abstract

Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalNature
Volume468
Issue number7323
DOIs
Publication statusPublished - 2010 Nov 25

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Pollen
Arabidopsis
Plant Nectar
Facilitative Glucose Transport Proteins
Epididymis
Caenorhabditis elegans
Virulence
Blood Glucose
Seeds
Breast
Maintenance
Glucose
Liver
Genes
Oryza

All Science Journal Classification (ASJC) codes

  • General

Cite this

Chen, L. Q., Hou, B. H., Lalonde, S., Takanaga, H., Hartung, M. L., Qu, X. Q., ... Frommer, W. B. (2010). Sugar transporters for intercellular exchange and nutrition of pathogens. Nature, 468(7323), 527-532. https://doi.org/10.1038/nature09606
Chen, Li Qing ; Hou, Bi Huei ; Lalonde, Sylvie ; Takanaga, Hitomi ; Hartung, Mara L. ; Qu, Xiao Qing ; Guo, Woei-Jiun ; Kim, Jung Gun ; Underwood, William ; Chaudhuri, Bhavna ; Chermak, Diane ; Antony, Ginny ; White, Frank F. ; Somerville, Shauna C. ; Mudgett, Mary Beth ; Frommer, Wolf B. / Sugar transporters for intercellular exchange and nutrition of pathogens. In: Nature. 2010 ; Vol. 468, No. 7323. pp. 527-532.
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Chen, LQ, Hou, BH, Lalonde, S, Takanaga, H, Hartung, ML, Qu, XQ, Guo, W-J, Kim, JG, Underwood, W, Chaudhuri, B, Chermak, D, Antony, G, White, FF, Somerville, SC, Mudgett, MB & Frommer, WB 2010, 'Sugar transporters for intercellular exchange and nutrition of pathogens', Nature, vol. 468, no. 7323, pp. 527-532. https://doi.org/10.1038/nature09606

Sugar transporters for intercellular exchange and nutrition of pathogens. / Chen, Li Qing; Hou, Bi Huei; Lalonde, Sylvie; Takanaga, Hitomi; Hartung, Mara L.; Qu, Xiao Qing; Guo, Woei-Jiun; Kim, Jung Gun; Underwood, William; Chaudhuri, Bhavna; Chermak, Diane; Antony, Ginny; White, Frank F.; Somerville, Shauna C.; Mudgett, Mary Beth; Frommer, Wolf B.

In: Nature, Vol. 468, No. 7323, 25.11.2010, p. 527-532.

Research output: Contribution to journalArticle

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AU - Chermak, Diane

AU - Antony, Ginny

AU - White, Frank F.

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AU - Mudgett, Mary Beth

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Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ et al. Sugar transporters for intercellular exchange and nutrition of pathogens. Nature. 2010 Nov 25;468(7323):527-532. https://doi.org/10.1038/nature09606