Supamolecular assemblies for delivery of nucleic acid medicines

Motoi Oishi; Nobuhiro Nishiyama; Keiji Itaka; Atsushi Ishii; Motoki Takagi; Akira Shimamoto; Yasuhiro Furuichi; Kazunori Kataoka; Yukio Nagasaki

Supamolecular assemblies for delivery of nucleic acid medicines

Motoi Oishi
, Nobuhiro Nishiyama
, Keiji Itaka
, Atsushi Ishii
, Motoki Takagi
, Akira Shimamoto
, Yasuhiro Furuichi
, Kazunori Kataoka
, Yukio Nagasaki

Center of Applied Nanomedicine

Research output: Contribution to conference › Paper › peer-review

Abstract

The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling PEG-siRNA conjugates bearing ligand molecules into polyion complex (PIC) micelles through the mixing with poly(L-lysine). The enhanced tumor growth inhibition in hepatic muticellular tumor spheroids was achieved by PIC micelle. This study has opened a new opportunity of the PIC micelles as siRNA therapeutics.

Original language	English
Pages	5268-5269
Number of pages	2
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sept 20 → 2006 Sept 22

Conference

Conference	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	06-09-20 → 06-09-22

All Science Journal Classification (ASJC) codes

General Engineering

Cite this

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title = "Supamolecular assemblies for delivery of nucleic acid medicines",

abstract = "The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling PEG-siRNA conjugates bearing ligand molecules into polyion complex (PIC) micelles through the mixing with poly(L-lysine). The enhanced tumor growth inhibition in hepatic muticellular tumor spheroids was achieved by PIC micelle. This study has opened a new opportunity of the PIC micelles as siRNA therapeutics.",

author = "Motoi Oishi and Nobuhiro Nishiyama and Keiji Itaka and Atsushi Ishii and Motoki Takagi and Akira Shimamoto and Yasuhiro Furuichi and Kazunori Kataoka and Yukio Nagasaki",

year = "2006",

language = "English",

pages = "5268--5269",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - CONF

T1 - Supamolecular assemblies for delivery of nucleic acid medicines

AU - Oishi, Motoi

AU - Nishiyama, Nobuhiro

AU - Itaka, Keiji

AU - Ishii, Atsushi

AU - Takagi, Motoki

AU - Shimamoto, Akira

AU - Furuichi, Yasuhiro

AU - Kataoka, Kazunori

AU - Nagasaki, Yukio

PY - 2006

Y1 - 2006

N2 - The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling PEG-siRNA conjugates bearing ligand molecules into polyion complex (PIC) micelles through the mixing with poly(L-lysine). The enhanced tumor growth inhibition in hepatic muticellular tumor spheroids was achieved by PIC micelle. This study has opened a new opportunity of the PIC micelles as siRNA therapeutics.

AB - The remarkably enhanced gene silencing in hepatoma cells was achieved by assembling PEG-siRNA conjugates bearing ligand molecules into polyion complex (PIC) micelles through the mixing with poly(L-lysine). The enhanced tumor growth inhibition in hepatic muticellular tumor spheroids was achieved by PIC micelle. This study has opened a new opportunity of the PIC micelles as siRNA therapeutics.

UR - https://www.scopus.com/pages/publications/33846182309

UR - https://www.scopus.com/pages/publications/33846182309#tab=citedBy

M3 - Paper

AN - SCOPUS:33846182309

SP - 5268

EP - 5269

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Supamolecular assemblies for delivery of nucleic acid medicines

Abstract

Conference

All Science Journal Classification (ASJC) codes

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