Suppression of acute and chronic mesial temporal epilepsy by contralateral sensing and closed-loop optogenetic stimulation with proportional-plus-off control

Research output: Contribution to journalArticle

Abstract

A proportional-plus-off control of optogenetic stimulation is implemented using the sample entropy and frequency bands of contralateral depth EEG as the afferent signals for seizure detection and feedback control. The system is tested on mice with mesial temporal epilepsy, induced by lithium-pilocarpine injections. The hippocampus is photic stimulated through an optical fibre inserted using the stereotactic technique, and depth EEG from the hippocampus contralateral to the photic-stimulation site is used to calculate the sample entropy and frequency bands, which, in turn, are utilized to classify the types of seizures. According to a lookup table, the proportional-plus-off controller maps the SEn to the control signal and regulates the intensity of the photic stimulation to the hippocampus. The average rates of correct seizure detection are >90% in both acute and chronic stages. The average rates of successful seizure suppression are 86–98% in the acute stage and 94.3% in the chronic stage. The results indicate that the contralateral sensing and closed-loop proportional-plus-off control of optogenetic stimulation is feasible for seizure control.

Original languageEnglish
Pages (from-to)309-317
Number of pages9
JournalBiomedical Signal Processing and Control
Volume51
DOIs
Publication statusPublished - 2019 May 1

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Optogenetics
Epilepsy
Seizures
Electroencephalography
Hippocampus
Photic Stimulation
Frequency bands
Entropy
Table lookup
Stereotaxic Techniques
Optical Fibers
Pilocarpine
Feedback control
Optical fibers
Lithium
Controllers
Injections

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Health Informatics

Cite this

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title = "Suppression of acute and chronic mesial temporal epilepsy by contralateral sensing and closed-loop optogenetic stimulation with proportional-plus-off control",
abstract = "A proportional-plus-off control of optogenetic stimulation is implemented using the sample entropy and frequency bands of contralateral depth EEG as the afferent signals for seizure detection and feedback control. The system is tested on mice with mesial temporal epilepsy, induced by lithium-pilocarpine injections. The hippocampus is photic stimulated through an optical fibre inserted using the stereotactic technique, and depth EEG from the hippocampus contralateral to the photic-stimulation site is used to calculate the sample entropy and frequency bands, which, in turn, are utilized to classify the types of seizures. According to a lookup table, the proportional-plus-off controller maps the SEn to the control signal and regulates the intensity of the photic stimulation to the hippocampus. The average rates of correct seizure detection are >90{\%} in both acute and chronic stages. The average rates of successful seizure suppression are 86–98{\%} in the acute stage and 94.3{\%} in the chronic stage. The results indicate that the contralateral sensing and closed-loop proportional-plus-off control of optogenetic stimulation is feasible for seizure control.",
author = "Lin, {Bing Hong} and Ming-Shaung Ju and Chou-Ching Lin",
year = "2019",
month = "5",
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language = "English",
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pages = "309--317",
journal = "Biomedical Signal Processing and Control",
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AU - Ju, Ming-Shaung

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N2 - A proportional-plus-off control of optogenetic stimulation is implemented using the sample entropy and frequency bands of contralateral depth EEG as the afferent signals for seizure detection and feedback control. The system is tested on mice with mesial temporal epilepsy, induced by lithium-pilocarpine injections. The hippocampus is photic stimulated through an optical fibre inserted using the stereotactic technique, and depth EEG from the hippocampus contralateral to the photic-stimulation site is used to calculate the sample entropy and frequency bands, which, in turn, are utilized to classify the types of seizures. According to a lookup table, the proportional-plus-off controller maps the SEn to the control signal and regulates the intensity of the photic stimulation to the hippocampus. The average rates of correct seizure detection are >90% in both acute and chronic stages. The average rates of successful seizure suppression are 86–98% in the acute stage and 94.3% in the chronic stage. The results indicate that the contralateral sensing and closed-loop proportional-plus-off control of optogenetic stimulation is feasible for seizure control.

AB - A proportional-plus-off control of optogenetic stimulation is implemented using the sample entropy and frequency bands of contralateral depth EEG as the afferent signals for seizure detection and feedback control. The system is tested on mice with mesial temporal epilepsy, induced by lithium-pilocarpine injections. The hippocampus is photic stimulated through an optical fibre inserted using the stereotactic technique, and depth EEG from the hippocampus contralateral to the photic-stimulation site is used to calculate the sample entropy and frequency bands, which, in turn, are utilized to classify the types of seizures. According to a lookup table, the proportional-plus-off controller maps the SEn to the control signal and regulates the intensity of the photic stimulation to the hippocampus. The average rates of correct seizure detection are >90% in both acute and chronic stages. The average rates of successful seizure suppression are 86–98% in the acute stage and 94.3% in the chronic stage. The results indicate that the contralateral sensing and closed-loop proportional-plus-off control of optogenetic stimulation is feasible for seizure control.

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