Surface and blood‐contacting properties of alkylsiloxane monolayers supported on silicone rubber

James H. Silver; Robert W. Hergenrother; Jui‐Che ‐C Lin; Florencia Lim; Horng‐Ban ‐B Lin; Toshiyuki Okada; Manoj K. Chaudhury; Stuart L. Cooper

doi:10.1002/jbm.820290414

Surface and blood‐contacting properties of alkylsiloxane monolayers supported on silicone rubber

James H. Silver, Robert W. Hergenrother, Jui‐Che ‐C Lin, Florencia Lim, Horng‐Ban ‐B Lin, Toshiyuki Okada, Manoj K. Chaudhury, Stuart L. Cooper

Department of Chemical Engineering

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Self‐assembled monolayers of alkylsiloxanes supported on polydimethyl siloxane (PDMS) rubber were used as model systems to study the relation between blood compatibility and surface chemistry. The inner lumen of PDMS tubes was first treated with an oxygen plasma. The resultant oxidized surfaces were postderivatized by reacting them with alkyltrichlorosilanes to form the monolayer films. The chemical properties of the monolayers were controlled by varying the head‐group chemical compositions. Surface derivatization was verified using variable‐angle X‐ray photoelectron spectroscopy (XPS or ESCA). Blood compatibility was evaluated using a canine ex vivo arteriovenous series shunt model. Surfaces grafted with hydrophobic head‐groups as ‐CH₃ and ‐CF₃ had significantly lower platelet and fibrinogen deposition than the surfaces composed of hydrophilic groups such as ‐CO₂CH₃, ‐(CH₂CH₂O)₃COCH₃, and ‐(OCH₂CH₂)₃OH. © 1995 John Wiley & Sons, Inc.

Original language	English
Pages (from-to)	535-548
Number of pages	14
Journal	Journal of Biomedical Materials Research
Volume	29
Issue number	4
DOIs	https://doi.org/10.1002/jbm.820290414
Publication status	Published - 1995 Apr

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering

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title = "Surface and blood‐contacting properties of alkylsiloxane monolayers supported on silicone rubber",

abstract = "Self‐assembled monolayers of alkylsiloxanes supported on polydimethyl siloxane (PDMS) rubber were used as model systems to study the relation between blood compatibility and surface chemistry. The inner lumen of PDMS tubes was first treated with an oxygen plasma. The resultant oxidized surfaces were postderivatized by reacting them with alkyltrichlorosilanes to form the monolayer films. The chemical properties of the monolayers were controlled by varying the head‐group chemical compositions. Surface derivatization was verified using variable‐angle X‐ray photoelectron spectroscopy (XPS or ESCA). Blood compatibility was evaluated using a canine ex vivo arteriovenous series shunt model. Surfaces grafted with hydrophobic head‐groups as ‐CH3 and ‐CF3 had significantly lower platelet and fibrinogen deposition than the surfaces composed of hydrophilic groups such as ‐CO2CH3, ‐(CH2CH2O)3COCH3, and ‐(OCH2CH2)3OH. {\textcopyright} 1995 John Wiley & Sons, Inc.",

author = "Silver, {James H.} and Hergenrother, {Robert W.} and Lin, {Jui‐Che ‐C} and Florencia Lim and Lin, {Horng‐Ban ‐B} and Toshiyuki Okada and Chaudhury, {Manoj K.} and Cooper, {Stuart L.}",

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AU - Silver, James H.

AU - Hergenrother, Robert W.

AU - Lin, Jui‐Che ‐C

AU - Lim, Florencia

AU - Lin, Horng‐Ban ‐B

AU - Okada, Toshiyuki

AU - Chaudhury, Manoj K.

AU - Cooper, Stuart L.

PY - 1995/4

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N2 - Self‐assembled monolayers of alkylsiloxanes supported on polydimethyl siloxane (PDMS) rubber were used as model systems to study the relation between blood compatibility and surface chemistry. The inner lumen of PDMS tubes was first treated with an oxygen plasma. The resultant oxidized surfaces were postderivatized by reacting them with alkyltrichlorosilanes to form the monolayer films. The chemical properties of the monolayers were controlled by varying the head‐group chemical compositions. Surface derivatization was verified using variable‐angle X‐ray photoelectron spectroscopy (XPS or ESCA). Blood compatibility was evaluated using a canine ex vivo arteriovenous series shunt model. Surfaces grafted with hydrophobic head‐groups as ‐CH3 and ‐CF3 had significantly lower platelet and fibrinogen deposition than the surfaces composed of hydrophilic groups such as ‐CO2CH3, ‐(CH2CH2O)3COCH3, and ‐(OCH2CH2)3OH. © 1995 John Wiley & Sons, Inc.

AB - Self‐assembled monolayers of alkylsiloxanes supported on polydimethyl siloxane (PDMS) rubber were used as model systems to study the relation between blood compatibility and surface chemistry. The inner lumen of PDMS tubes was first treated with an oxygen plasma. The resultant oxidized surfaces were postderivatized by reacting them with alkyltrichlorosilanes to form the monolayer films. The chemical properties of the monolayers were controlled by varying the head‐group chemical compositions. Surface derivatization was verified using variable‐angle X‐ray photoelectron spectroscopy (XPS or ESCA). Blood compatibility was evaluated using a canine ex vivo arteriovenous series shunt model. Surfaces grafted with hydrophobic head‐groups as ‐CH3 and ‐CF3 had significantly lower platelet and fibrinogen deposition than the surfaces composed of hydrophilic groups such as ‐CO2CH3, ‐(CH2CH2O)3COCH3, and ‐(OCH2CH2)3OH. © 1995 John Wiley & Sons, Inc.

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Surface and blood‐contacting properties of alkylsiloxane monolayers supported on silicone rubber

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