Surface characterization and platelet compatibility evaluation of binary mixed self-assembled monolayers containing novel sulfonic acid terminated alkanethiol

Ching Hsiung Shen, Jui-Che Lin

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The interactions between the biological environment and artificial surface are greatly influenced by the surface characteristics of substrate. Self-assembled monolayer prepared by long-chain alkanethiol on gold has been considered as a good model surface to study the effects of surface characteristics upon biological responses. In this study, two different series of mixed SAMs prepared by lab-synthesized sulfonic acid terminated alkanethiol with hydrophobic -CH3 or hydrophilic -OH terminated one were characterized. It was noted that the surface hydrophilicity of -SO3H/-CH3 mixed SAMs was increased with the solution mole fraction of -SO3H terminated thiol. However, the surfaces were all hydrophilic on the -SO3H/-OH mixed SAMs. All of these mixed SAMs were " -SO3H poor" and negatively charged on surface. In vitro platelet adhesion study indicated that -SO3H/-OH mixed SAMs exhibited a better platelet compatibility than -SO3H/-CH3 mixed ones, suggesting a surface with fair hydrophilicity and least negative surface charges might be of potential as a candidate for developing a platelet/blood compatible artificial surface.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume79
Issue number1
DOIs
Publication statusPublished - 2010 Aug 1

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

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