Surface characterization and platelet compatibility evaluation of the binary mixed self-assembled monolayers

Meng Yen Tsai, Yu Ting Sun, Jui-Che Lin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This report describes a technique that used mixed self-assembled monolayer (SAM) as a model surface to evaluate the effect of steric hindrance on the SAM packing quality and its platelet compatibility. Two series of binary mixed SAMs were formed by mixing the bulky terminated alkanethiol (HS(CH2)10PO3H2) with a smaller terminated one (HS(CH2)9CH3 and HS(CH2)11OH) respectively. Surface characterization results showed the hydrophilicity on these two series of mixed SAMs changed with the solution mole fraction of {single bond}PO3H2 terminated thiol, χPO3H2,soln, and reached to a nearly constant value as χPO3H2,soln was 0.6 for PO3H2 + CH3 SAM and 0.4 for PO3H2 + OH SAM. This finding should be due to the gradual saturation of surface {single bond}PO3H2 functionality on these mixed SAMs. The XPS analysis indicated the addition of the {single bond}CH3 and {single bond}OH terminated thiol could reduce the steric hindrance effect of {single bond}PO3H2 functionality on monolayer formation and, henceforth, improve the SAM packing quality. In vitro platelet adhesion assay revealed the platelet compatibility on the PO3H2 + OH SAMs was better than that on the PO3H2 + CH3 and the pure {single bond}PO3H2 ones. Moreover, the PO3H2 + OH SAM with a low χPO3H2,soln value exhibited the least platelet activating property of these two mixed SAM systems. These findings suggested that material's surface wettability and surface charge density should act collectively in affecting its platelet compatibility.

Original languageEnglish
Pages (from-to)474-484
Number of pages11
JournalJournal of Colloid And Interface Science
Volume308
Issue number2
DOIs
Publication statusPublished - 2007 Apr 15

Fingerprint

Self assembled monolayers
Platelets
Sulfhydryl Compounds
Hydrophilicity
Surface charge
Charge density
Wetting
single bond
Monolayers
Assays
Adhesion
X ray photoelectron spectroscopy

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

@article{eb53c4d988cd4a2699d77d422621da03,
title = "Surface characterization and platelet compatibility evaluation of the binary mixed self-assembled monolayers",
abstract = "This report describes a technique that used mixed self-assembled monolayer (SAM) as a model surface to evaluate the effect of steric hindrance on the SAM packing quality and its platelet compatibility. Two series of binary mixed SAMs were formed by mixing the bulky terminated alkanethiol (HS(CH2)10PO3H2) with a smaller terminated one (HS(CH2)9CH3 and HS(CH2)11OH) respectively. Surface characterization results showed the hydrophilicity on these two series of mixed SAMs changed with the solution mole fraction of {single bond}PO3H2 terminated thiol, χPO3H2,soln, and reached to a nearly constant value as χPO3H2,soln was 0.6 for PO3H2 + CH3 SAM and 0.4 for PO3H2 + OH SAM. This finding should be due to the gradual saturation of surface {single bond}PO3H2 functionality on these mixed SAMs. The XPS analysis indicated the addition of the {single bond}CH3 and {single bond}OH terminated thiol could reduce the steric hindrance effect of {single bond}PO3H2 functionality on monolayer formation and, henceforth, improve the SAM packing quality. In vitro platelet adhesion assay revealed the platelet compatibility on the PO3H2 + OH SAMs was better than that on the PO3H2 + CH3 and the pure {single bond}PO3H2 ones. Moreover, the PO3H2 + OH SAM with a low χPO3H2,soln value exhibited the least platelet activating property of these two mixed SAM systems. These findings suggested that material's surface wettability and surface charge density should act collectively in affecting its platelet compatibility.",
author = "Tsai, {Meng Yen} and Sun, {Yu Ting} and Jui-Che Lin",
year = "2007",
month = "4",
day = "15",
doi = "10.1016/j.jcis.2007.01.015",
language = "English",
volume = "308",
pages = "474--484",
journal = "Journal of Colloid and Interface Science",
issn = "0021-9797",
publisher = "Academic Press Inc.",
number = "2",

}

Surface characterization and platelet compatibility evaluation of the binary mixed self-assembled monolayers. / Tsai, Meng Yen; Sun, Yu Ting; Lin, Jui-Che.

In: Journal of Colloid And Interface Science, Vol. 308, No. 2, 15.04.2007, p. 474-484.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Surface characterization and platelet compatibility evaluation of the binary mixed self-assembled monolayers

AU - Tsai, Meng Yen

AU - Sun, Yu Ting

AU - Lin, Jui-Che

PY - 2007/4/15

Y1 - 2007/4/15

N2 - This report describes a technique that used mixed self-assembled monolayer (SAM) as a model surface to evaluate the effect of steric hindrance on the SAM packing quality and its platelet compatibility. Two series of binary mixed SAMs were formed by mixing the bulky terminated alkanethiol (HS(CH2)10PO3H2) with a smaller terminated one (HS(CH2)9CH3 and HS(CH2)11OH) respectively. Surface characterization results showed the hydrophilicity on these two series of mixed SAMs changed with the solution mole fraction of {single bond}PO3H2 terminated thiol, χPO3H2,soln, and reached to a nearly constant value as χPO3H2,soln was 0.6 for PO3H2 + CH3 SAM and 0.4 for PO3H2 + OH SAM. This finding should be due to the gradual saturation of surface {single bond}PO3H2 functionality on these mixed SAMs. The XPS analysis indicated the addition of the {single bond}CH3 and {single bond}OH terminated thiol could reduce the steric hindrance effect of {single bond}PO3H2 functionality on monolayer formation and, henceforth, improve the SAM packing quality. In vitro platelet adhesion assay revealed the platelet compatibility on the PO3H2 + OH SAMs was better than that on the PO3H2 + CH3 and the pure {single bond}PO3H2 ones. Moreover, the PO3H2 + OH SAM with a low χPO3H2,soln value exhibited the least platelet activating property of these two mixed SAM systems. These findings suggested that material's surface wettability and surface charge density should act collectively in affecting its platelet compatibility.

AB - This report describes a technique that used mixed self-assembled monolayer (SAM) as a model surface to evaluate the effect of steric hindrance on the SAM packing quality and its platelet compatibility. Two series of binary mixed SAMs were formed by mixing the bulky terminated alkanethiol (HS(CH2)10PO3H2) with a smaller terminated one (HS(CH2)9CH3 and HS(CH2)11OH) respectively. Surface characterization results showed the hydrophilicity on these two series of mixed SAMs changed with the solution mole fraction of {single bond}PO3H2 terminated thiol, χPO3H2,soln, and reached to a nearly constant value as χPO3H2,soln was 0.6 for PO3H2 + CH3 SAM and 0.4 for PO3H2 + OH SAM. This finding should be due to the gradual saturation of surface {single bond}PO3H2 functionality on these mixed SAMs. The XPS analysis indicated the addition of the {single bond}CH3 and {single bond}OH terminated thiol could reduce the steric hindrance effect of {single bond}PO3H2 functionality on monolayer formation and, henceforth, improve the SAM packing quality. In vitro platelet adhesion assay revealed the platelet compatibility on the PO3H2 + OH SAMs was better than that on the PO3H2 + CH3 and the pure {single bond}PO3H2 ones. Moreover, the PO3H2 + OH SAM with a low χPO3H2,soln value exhibited the least platelet activating property of these two mixed SAM systems. These findings suggested that material's surface wettability and surface charge density should act collectively in affecting its platelet compatibility.

UR - http://www.scopus.com/inward/record.url?scp=33847223746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847223746&partnerID=8YFLogxK

U2 - 10.1016/j.jcis.2007.01.015

DO - 10.1016/j.jcis.2007.01.015

M3 - Article

VL - 308

SP - 474

EP - 484

JO - Journal of Colloid and Interface Science

JF - Journal of Colloid and Interface Science

SN - 0021-9797

IS - 2

ER -