Surface modification of titanium substrate with a novel covalently-bound copolymer thin film for improving its platelet compatibility

Ching Hsiung Shen, Yu Jen Cho, Yi Ching Lin, Li Chin Chien, Tzer Min Lee, Wen Hsi Chuang, Jui Che Lin

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Despite of its widely uses in various clinical applications, the titanium-based material still faces different challenges, such as hemocompatibility and anti-biofouling characteristics required in various situations. The objective of this investigation was to develop a novel surface modification strategy for titanium-based material to improve the platelet compatibility that is important in rigorous blood-contacting cardiovascular applications. In this work, a series of copolymers, which composed of novel 6-acryloyloxy hexyl phosphonic acid (AcrHPA) and sulfobetaine methacrylate (SBMA) was synthesized. The phosphonic acid group in these copolymers can impart covalent binding to the titanium substrate while the zwitterionic sulfobetaine functionality is considered being able to reduce the platelet adhesion and activation on the modified titanium substrate. NMR analyses suggested that copolymerization reaction is likely not an ideal statistical reaction but to add the monomers in a random order. Studies have shown that the composition of the monomers affected the surface characteristics and platelet compatibility of these covalent-bound AcrHPA–SBMA copolymers on titanium substrate. Contact angle analysis has shown the addition of SBMA can increase surface hydrophilicity of the spun-coated copolymers. In addition, AFM analyses have revealed that the surface roughness of the spun-coated copolymer layer were varied with the ratio of AcrHPA and SBMA. The most platelet compatible surface was noted on the one modified by the highest amount of SBMA added (i.e. 70 mol%) in copolymerization. In summary, the surface modification scheme presented here would be of potential as well as manufacturing process applicable for future development in blood-contacting titanium-based biomedical devices.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalJournal of Materials Science: Materials in Medicine
Issue number2
Publication statusPublished - 2015 Feb

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Surface modification of titanium substrate with a novel covalently-bound copolymer thin film for improving its platelet compatibility'. Together they form a unique fingerprint.

Cite this