Surface reaction of stoichiometric and calcium-deficient hvdroxyapatite in simulated body fluid

J. H.C. Lin, K. H. Kuo, S. J. Ding, C. P. Ju

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


In the present study, the immersion behavior of two kinds of sintered HA with different Ca/P ratios in two different extracellular simulated solutions (Tris buffer and Hank's solutions) was investigated and compared. Results indicated that an as-received Ca-deficient HA (FHA) had a lower Ca/P ratio, larger linear shrinkage and higher density than a stoichiometric HA (MHA). When FHA powder was calcined at 900 °C, its Ca-deficient apatite structure was unstable and a significant amount of β-TCP phase was formed. When heated to 1250 °C in air, the highly crystalline apatite structure of MHA was still stable without any noticeable decomposition. The FTIR spectra indicated that both immersed MHA and FHA in Hank's solution were gradually covered with a layer of precipitated apatite during immersion. When immersed in Tris buffer solution, neither HA showed significant changes in their FTIR spectra. SEM observation indicated that the precipitation rate on immersed FHA surface was much higher than that on MHA surface when immersed in Hank's solution. The weight loss and pH data confirmed the higher dissolution rate of FHA than MHA in Hank's solution.

Original languageEnglish
Pages (from-to)731-741
Number of pages11
JournalJournal of Materials Science: Materials in Medicine
Issue number8
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering


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