Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices

Po-Wu Gean, Chiung Chun Huang, Jju Home Lin, Jing Jane Tsai

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effect of isoproterenol (Iso) on synaptic transmission mediated by the N-methyl-d-aspartate (NMDA) receptors (EPSPNMDA) was investigated in slices of rat amygdala using intracellular recording techniques. EPSPNMDA was isolated pharmacologically by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 μM) and GABAA receptor blocker bicuculline (20 μM). Superfusion of Iso (15 μM) produced a long-lasting enhancement of EPSPNMDA. Pretreatment the slices with propranolol (10 μM) completely prevented the effect of Iso confirming the mediation by β-adrenergic receptors. These results provide the direct evidence for adrenergic modulation of excitatory amino acid neurotransmission in the vertebrate central nervous system.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalBrain Research
Volume594
Issue number2
DOIs
Publication statusPublished - 1992 Oct 30

Fingerprint

Synaptic Potentials
Isoproterenol
6-Cyano-7-nitroquinoxaline-2,3-dione
Synaptic Transmission
Excitatory Amino Acids
Bicuculline
GABA-A Receptors
Amygdala
Propranolol
Adrenergic Agents
Adrenergic Receptors
Vertebrates
Central Nervous System
aspartic acid receptor

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Gean, Po-Wu ; Huang, Chiung Chun ; Lin, Jju Home ; Tsai, Jing Jane. / Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices. In: Brain Research. 1992 ; Vol. 594, No. 2. pp. 331-334.
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Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices. / Gean, Po-Wu; Huang, Chiung Chun; Lin, Jju Home; Tsai, Jing Jane.

In: Brain Research, Vol. 594, No. 2, 30.10.1992, p. 331-334.

Research output: Contribution to journalArticle

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