Sustained enhancement of NMDA receptor-mediated synaptic potential by isoproterenol in rat amygdalar slices

Po Wu Gean, Chiung Chun Huang, Jju Home Lin, Jing Jane Tsai

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The effect of isoproterenol (Iso) on synaptic transmission mediated by the N-methyl-d-aspartate (NMDA) receptors (EPSPNMDA) was investigated in slices of rat amygdala using intracellular recording techniques. EPSPNMDA was isolated pharmacologically by application of a solution containing the non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 10 μM) and GABAA receptor blocker bicuculline (20 μM). Superfusion of Iso (15 μM) produced a long-lasting enhancement of EPSPNMDA. Pretreatment the slices with propranolol (10 μM) completely prevented the effect of Iso confirming the mediation by β-adrenergic receptors. These results provide the direct evidence for adrenergic modulation of excitatory amino acid neurotransmission in the vertebrate central nervous system.

Original languageEnglish
Pages (from-to)331-334
Number of pages4
JournalBrain Research
Volume594
Issue number2
DOIs
Publication statusPublished - 1992 Oct 30

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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