Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

S. Ja Tseng; Yi Fang Zeng; Yu Fan Deng; Pan Chyr Yang; Je Ruei Liu; Ivan M. Kempson

doi:10.1039/c3cc00134b

Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

S. Ja Tseng, Yi Fang Zeng, Yu Fan Deng, Pan Chyr Yang, Je Ruei Liu, Ivan M. Kempson

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

Original language	English
Pages (from-to)	2670-2672
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	26
DOIs	https://doi.org/10.1039/c3cc00134b
Publication status	Published - 2013 Mar 5

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c3cc00134b

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abstract = "A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.",

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AU - Yang, Pan Chyr

AU - Liu, Je Ruei

AU - Kempson, Ivan M.

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AB - A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

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Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex

Abstract

All Science Journal Classification (ASJC) codes

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