Sympathetic hyperactivity in Wistar rats with insulin-resistance

Chih Jen Chang; Jin Shang Wu; Feng Hwa Lu; I. Min Liu; Tzong Cherng Chi; Juei Tang Cheng

doi:10.1016/S0165-1838(98)00143-X

Sympathetic hyperactivity in Wistar rats with insulin-resistance

Chih Jen Chang, Jin Shang Wu, Feng Hwa Lu, I. Min Liu, Tzong Cherng Chi, Juei Tang Cheng

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. Copyright (C) 1998 Elsevier Science B.V.

Original language	English
Pages (from-to)	116-119
Number of pages	4
Journal	Journal of the Autonomic Nervous System
Volume	74
Issue number	2-3
DOIs	https://doi.org/10.1016/S0165-1838(98)00143-X
Publication status	Published - 1998 Dec 11

All Science Journal Classification (ASJC) codes

General Neuroscience
Physiology
Clinical Neurology

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title = "Sympathetic hyperactivity in Wistar rats with insulin-resistance",

abstract = "In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. Copyright (C) 1998 Elsevier Science B.V.",

author = "Chang, {Chih Jen} and Wu, {Jin Shang} and Lu, {Feng Hwa} and Liu, {I. Min} and Chi, {Tzong Cherng} and Cheng, {Juei Tang}",

note = "Funding Information: We thank Miss S.M. Tai for her excellent technical assistance. The present study is supported in part by a grant from the Hospital Research Foundation for Dr J.S. Wu (NCKH-FR-86-41).",

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T1 - Sympathetic hyperactivity in Wistar rats with insulin-resistance

AU - Chang, Chih Jen

AU - Wu, Jin Shang

AU - Lu, Feng Hwa

AU - Liu, I. Min

AU - Chi, Tzong Cherng

AU - Cheng, Juei Tang

N1 - Funding Information: We thank Miss S.M. Tai for her excellent technical assistance. The present study is supported in part by a grant from the Hospital Research Foundation for Dr J.S. Wu (NCKH-FR-86-41).

PY - 1998/12/11

Y1 - 1998/12/11

N2 - In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. Copyright (C) 1998 Elsevier Science B.V.

AB - In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. Copyright (C) 1998 Elsevier Science B.V.

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ER -

Sympathetic hyperactivity in Wistar rats with insulin-resistance

Abstract

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