Sympathetic hyperactivity in Wistar rats with insulin-resistance

Chih Jen Chang, Jin Shang Wu, Feng Hwa Lu, I. Min Liu, Tzong Cherng Chi, Juei Tang Cheng

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11 Citations (Scopus)


In an attempt to know the effect of sustained hyperinsulinemia on sympathetic function, plasma norepinephrine (NE) and glucose levels were measured in Wistar rats with insulin resistance. Both the basal plasma glucose and the plasma NE levels in insulin-resistant rats were markedly higher than that obtained in normal or streptozotocin (STZ)-induced diabetic rats. Treatment with guanethidine and prazosin reversed these sympathetic hyperactive responses in insulin-resistant rats. Moreover, increase of plasma insulin in rats receiving an intraperitoneal glucose challenge test confirmed the mediation of endogenous insulin in this sympathetic hyperactivity. These results suggest an increase of sympathetic activity in insulin-resistant state that may be related to the hypertension-prone associated with diabetes mellitus in clinics. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalJournal of the Autonomic Nervous System
Issue number2-3
Publication statusPublished - 1998 Dec 11

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology


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